Moderate Cosmetic Ingredient NOAEL Data SCCS/CIR Reviewed

Disperse Violet 1

Also known as: C.I. Disperse Violet 9, 1,4-Anthraquinonyldiamine, Celliton Fast Red Violet R, Cibacet Violet E2R, Cibacete Violet 2R (+10 more)

INCI: DISPERSE VIOLET 1

Disperse Violet 1 (CAS 128-95-0) is a cosmetic cosmetic ingredient functioning as Hair dyeing (anthraquinone dye); non-oxidative colouring agent. Reported NOAEL =1.21 mg/kg in guinea pig (SCCNFP Opinion); EU Regulation 1223/2009 status: prohibited, max 0.5%; 1 safety opinion reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 128-95-0 →

Auto-generated CPSR Part A draft with source citations
Function
Hair dyeing (anthraquinone dye); non-oxidative colouring agent
Safety Rating
MODERATE

Chemistry & Identifiers

Formula
C14H10N2O2
MW
238.24 g/mol
PubChem CID
31420
IUPAC Name
1,4-diaminoanthracene-9,10-dione
InChIKey
FBMQNRKSAWNXBT-UHFFFAOYSA-N

Regulatory Status

EU EU Status prohibited
EU Max Conc. 0.5%
US US Status permitted
US Notes Not specifically listed under 21 CFR 73/74/82; coal tar exemption applies with labeling

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Disperse Violet 1.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Disperse Violet 1. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =1.21 mg/kg - guinea pig irritation SCCNFP Opinion
NOAEL =1.21 mg/kg/day oral rat repeated dose toxicity SCCNFP Opinion
NOAEL =1.21 mg/kg - guinea pig irritation SCCNFP Opinion
NOAEL =1.21 mg/kg/day oral rat repeated dose toxicity SCCNFP Opinion
NOAEL =1.21 mg/kg - guinea pig irritation SCCNFP Opinion
NOAEL =1.21 mg/kg/day oral rat repeated dose toxicity SCCNFP Opinion
NOAEL =1.21 mg/kg - guinea pig irritation SCCNFP Opinion
NOAEL =1.21 mg/kg/day oral rat repeated dose toxicity SCCNFP Opinion
NOAEL =0.003 mg/kg bw oral rat dermal absorption SCCS Opinion
NOAEL =0.003 mg/kg bw oral rat dermal absorption SCCS Opinion

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

CIR Safety Assessment
Verdict: unknown

Expanded Jurisdictional Detail

Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.

SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in non-oxidative hair dye products. Max: 0.005.
BRIN Brazil/India Cosmetics
India: Restricted · max 0.005
Additional Jurisdictional Restrictions (1)
Jurisdiction Status Max % Product Type
CN permitted_hair_dye 0.5 Non-oxidative hair dye

Additional Ingredient Properties

1 property record from structured ingredient metadata.

hair_dye
{"cas_number": "128-95-0", "ingredient_class": "direct_dye", "color_index_CI_number": "61100", "chemical_class": "anthraquinone", "color_result_on_hair": "Violet", "shade_range": "fashion_color", "primary_function": "direct_deposit", "requires_developer": "no", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-12", "light_fastness": "good", "oxidation_mechanism": …

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database

Expert Verdict

Expert safety assessment and concern-level summary for Disperse Violet 1.

Regulatory Flags

potential-allergen eu_cosing_listed

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Disperse Violet 1 by CAS number or substance name.

Studies
32
Lowest NOAEL
0.003
Highest NOAEL
160

Units vary across source rows: mg/kg bw, mg/kg, mg/kg/day

SCCS Opinion SCCNFP Opinion

Known Synonyms

C.I. Disperse Violet 9 1,4-Anthraquinonyldiamine Celliton Fast Red Violet R Cibacet Violet E2R Cibacete Violet 2R 1,4-Diamino-9-10-anthraquinone Dispersive Violet K Duranol Violet 2R, 1,4-diamino- EINECS 204-922-6 Interchem Disperse Violet 2RH Lurafix Red Violet RN Mideton Fast Red Violet R Seacyl Violet R Sectacyl Violet Propyl C.I. 61100

Chemical Function

Dye

Regulatory Lists

Europe; Personal care; restricted inert_ingredient; non_food_use; Pesticides Europe; Personal care - hair coloring Europe; Personal care - hair coloring

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

ChEMBL ID
CHEMBL86771
View full pharmaceutical profile →

Frequently Asked Questions

Is Disperse Violet 1 safe in cosmetics?

Disperse Violet 1 has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.

Is Disperse Violet 1 allowed in the EU?

Disperse Violet 1 EU regulatory status: prohibited. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.

What does Disperse Violet 1 do in cosmetics?

Disperse Violet 1 functions as: Hair dyeing (anthraquinone dye); non-oxidative colouring agent. It is classified as a cosmetic ingredient in our database. CAS number: 128-95-0.

What is the NOAEL for Disperse Violet 1?

The NOAEL (No Observed Adverse Effect Level) for Disperse Violet 1 is =1.21 mg/kg based on a irritation study via oral route in guinea pig. A total of 10 study endpoints are available. Source: SCCNFP Opinion.

Is Disperse Violet 1 used outside cosmetics?

Disperse Violet 1 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does Disperse Violet 1 have different safety status in cosmetics vs industrial chemicals?

Disperse Violet 1 is prohibited in EU cosmetics at max 0.5% but has active industrial GHS classifications (H301, H317, H373).

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