What is the NOAEL for Sulfan blue?
Sulfan blue has 12 NOAEL studies in the database. The lowest reported value is 13.557 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
IARC Group 3
REACH Registered
Cosmetic Ingredient
Sulfan blue
Also known as: C.I. Food Blue 3, Patent Blue VF, Patent Blue Violet, C.I. Acid Blue 1, sodium salt, C.I. Acid Blue 1 (+15 more)
CAS 129-17-9
Sulfan blue (CAS 129-17-9) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH.
View cosmetic safety profile for CI 42045 (Acid Blue 1 / D&C Blue No. 4) →
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Sulfan blue
CAS Number
129-17-9
DTXSID
DTXSID3026065
Molecular Formula
C27H32N2O6S2.Na
InChI Key
SJEYSFABYSGQBG-UHFFFAOYSA-M
Synonyms
C.I. Food Blue 3Patent Blue VFPatent Blue VioletC.I. Acid Blue 1, sodium saltC.I. Acid Blue 1Acid Blue VAcid Blue 1Acid bright azure ZAcid Brilliant Blue ZAcid Brilliant Blue VFAcid Brilliant Sky Blue ZAcid Leather Blue V
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1987 | 16, Sup 7 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| banned; Europe; Personal care | European Commission | CosIng |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =13.557 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| FH1929ICIT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FH1929ICIT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FH1929ICIT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FH1929ICIT | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 3 | unitless | IARC group | - | - | NTP_ICE_cancer |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =375 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =500 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Hydrogen [4-[4-(diethylamino)-2',4'-disulphonatobenzhydrylidene]cyclohexa-2,5-dien-1-ylidene]diethylammonium, sodium salt | 204-934-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
No maximum concentration specified for permitted applications. Prohibited in hair dye products (Annex II/1355). Prohibited in products applied to mucous membranes (Annex IV restriction). Purity per EU standards required.
Category
Colorants
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1731183
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Frequently Asked Questions
What regulatory lists include Sulfan blue?
Sulfan blue appears on 3 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, banned; Europe; Personal care, Canada; pharmaceutical. Source: EPA CPDat.
Is Sulfan blue a carcinogen according to IARC?
Sulfan blue is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1987). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Sulfan blue used in cosmetics?
Yes, Sulfan blue is also indexed as a cosmetic ingredient under the name CI 42045 (Acid Blue 1 / D&C Blue No. 4). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Sulfan blue come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Sulfan blue used outside industrial chemicals?
Sulfan blue also appears in cosmetics, pharmaceutical databases.