Also known as: C.I. Food Blue 3, Patent Blue VF, Patent Blue Violet, C.I. Acid Blue 1, sodium salt, C.I. Acid Blue 1 (+15 more)
INCI: CI 42045
CI 42045 (Acid Blue 1 / D&C Blue No. 4) (CAS 129-17-9) is a cosmetic cosmetic ingredient functioning as Colorant. Synthetic triphenylmethane blue dye (Acid Blue 1, also known as D&C. Reported NOAEL =375 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: restricted, max No maximum concentration specified for permitted applications. Prohibited in hair dye products (Annex II/1355). Prohibited in products applied to mucous membranes (Annex IV restriction). Purity per EU standards required.. Industrial safety data is also available in the chemical safety database. Same-CAS
View industrial chemical safety profile for CAS 129-17-9 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for CI 42045 (Acid Blue 1 / D&C Blue No. 4).
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2 study endpoints found for CI 42045 (Acid Blue 1 / D&C Blue No. 4). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =375 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =500 mg/kg bw/day | oral | Mouse | chronic | ToxValDB_ECHA_IUCLID |
International Agency for Research on Cancer (WHO) monograph evaluation.
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_colorant | - | Cosmetics except near eyes (Class 3) |
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Expert safety assessment and concern-level summary for CI 42045 (Acid Blue 1 / D&C Blue No. 4).
Public NOAEL study rows linked to CI 42045 (Acid Blue 1 / D&C Blue No. 4) by CAS number or substance name.
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
CI 42045 (Acid Blue 1 / D&C Blue No. 4) has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
CI 42045 (Acid Blue 1 / D&C Blue No. 4) EU regulatory status: restricted. Maximum allowed concentration: No maximum concentration specified for permitted applications. Prohibited in hair dye products (Annex II/1355). Prohibited in products applied to mucous membranes (Annex IV restriction). Purity per EU standards required.. This is based on EU Regulation 1223/2009 and its amendments.
CI 42045 (Acid Blue 1 / D&C Blue No. 4) functions as: Colorant. Synthetic triphenylmethane blue dye (Acid Blue 1, also known as D&C Blue No. 4, Food Blue 2). Imparts blue coloration to cosmetic and personal care products. Water-soluble anionic sulfonated triphenylmethane dye. Approved for limited cosmetic use under EU and US regulations, with key restrictions preventing use in hair dye products and limiting scope to non-mucosal applications.. It is classified as a cosmetic ingredient in our database. CAS number: 129-17-9.
The NOAEL (No Observed Adverse Effect Level) for CI 42045 (Acid Blue 1 / D&C Blue No. 4) is =375 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
CI 42045 (Acid Blue 1 / D&C Blue No. 4) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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