What is the NOAEL for Calcium oxide?
Calcium oxide has 8 NOAEL studies in the database. The lowest reported value is 1 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Calcium oxide
Also known as: CaO, Calcium oxide (CaO), Lime, Caloxol CP2, Calx usta (+15 more)
CAS 1305-78-8
Calcium oxide (CAS 1305-78-8) is a chemical substance. Key regulatory status: REACH registered, 19 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
Calcium oxide is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H314, H315, H318, H335, H303, H304, H370).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
19
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Calcium oxide
CAS Number
1305-78-8
DTXSID
DTXSID5029631
Molecular Formula
Ca.O
InChI Key
BRPQOXSCLDDYGP-UHFFFAOYSA-N
Monoisotopic Mass
55.957505
Synonyms
CaOCalcium oxide (CaO)LimeCaloxol CP2Calx ustaCaswell No. 147AChaux viveEINECS 215-138-9EPA Pesticide Chemical Code 075604Lime, burnedQuick limeUnslaked lime
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. The effects may be delayed. Medical observation is indicated. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged inhalation of dust particles may cause effects on the lungs. Repeated or prolonged inhalation may cause nasal ulceration. This may result in perforation of the nasal septum. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
4 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 5 mg/m³ | - | 5 | N |
| NIOSH | TWA | 2 mg/m³ | - | 2 | N |
| CAL/OSHA | TWA | 2 mg/m³ | - | 2 | N |
| NIOSH | IDLH | 25 mg/m³ | - | 25 | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
pH regulating agentStabilizing agentBinderDegradant/impurityFlux agentFillerDehydrating agent (desiccant)Catalyst
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
19 records
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| C7X2M0VVNH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C7X2M0VVNH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C7X2M0VVNH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C7X2M0VVNH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| 440 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 680 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Calcium oxide | 215-138-9 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
LIME
ChEMBL Phase
3
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E529 — ADI: NOT LIMITED mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Calcium oxide?
Calcium oxide appears on 11 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, inert_ingredient; Pesticides, active_ingredient; animal_products; Europe; pharmaceutical; residue, and 8 more. Source: EPA CPDat.
What are the occupational exposure limits for Calcium oxide?
Occupational exposure limits for Calcium oxide are set by OSHA, NIOSH, CAL/OSHA. 4 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Calcium oxide used in cosmetics?
Yes, Calcium oxide is also indexed as a cosmetic ingredient under the name Calcium Oxide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Calcium oxide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Calcium oxide have different safety status in cosmetics vs industrial chemicals?
Calcium oxide is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H314, H315, H318, H335, H303, H304, H370).
Is Calcium oxide used outside industrial chemicals?
Calcium oxide also appears in cosmetics, pharmaceutical, food safety, cannabis databases.