Poor Cosmetic Ingredient NOAEL Data GHS Classified

Calcium Oxide

INCI: CALCIUM OXIDE

CAS Number
1305-78-8
Function
Buffering agent
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Conditional — safe only at very low concentrations with strict pH control; MoS inadequate at high concentrations

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Calcium Oxide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 440 mg/kg bw/day oral mouse Developmental COSMOS_DB
NOAEL 680 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 680 mg/kg bw/day oral rat Reproductive COSMOS_DB
dose_tested 680 mg/kg bw/day oral rat Developmental COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. The effects may be delayed. Medical observation is indicated.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged inhalation of dust particles may cause effects on the lungs. Repeated or prolonged inhalation may cause nasal ulceration. This may result in perforation of the nasal septum.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Expert Verdict

Strong alkali (quicklime); exothermic reaction with water causing severe eye damage potential; respiratory irritant and skin corrosion risk at high concentrations; pH control and documentation mandatory with patch testing required; detailed risk assessment essential in CPSR.

⚠️
Concern Level: High

Regulatory Flags

fda_food_additive jecfa_safe

Frequently Asked Questions

Is Calcium Oxide safe in cosmetics?

Strong alkali (quicklime); exothermic reaction with water causing severe eye damage potential; respiratory irritant and skin corrosion risk at high concentrations; pH control and documentation mandatory with patch testing required; detailed risk assessment essential in CPSR. The EU classifies Calcium Oxide as "prohibited". Safety rating: POOR. 4 toxicological study endpoint(s) are available in our database.

Is Calcium Oxide allowed in the EU?

Calcium Oxide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Calcium Oxide do in cosmetics?

Calcium Oxide functions as: Buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 1305-78-8.

What is the Margin of Safety for Calcium Oxide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Calcium Oxide?

The NOAEL (No Observed Adverse Effect Level) for Calcium Oxide is 440 mg/kg bw/day based on a Developmental study via oral route in mouse. A total of 4 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Calcium Oxide compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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