NOAEL Data REACH Registered Cosmetic Ingredient

Dimethyl phthalate

Also known as: Caswell No. 380, Dimethyl benzene-o-dicarboxylate, Dimethyl benzeneorthodicarboxylate, EINECS 205-011-6, EPA Pesticide Chemical Code 028002 (+4 more)

CAS 131-11-3

Dimethyl phthalate (CAS 131-11-3) is a chemical substance. Key regulatory status: REACH registered, 14 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA, EPA TRI.

View cosmetic safety profile for Dimethyl Phthalate →

SOURCE noael studies public
NOAEL studies
100
SOURCE chemical inventory jurisdictions
Regulatory lists
14
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 15 fields
Name
Dimethyl phthalate
CAS Number
131-11-3
DTXSID
DTXSID3022455
Molecular Formula
C10H10O4
InChI Key
NIQCNGHVCWTJSM-UHFFFAOYSA-N
Monoisotopic Mass
194.057909
Synonyms
Caswell No. 380Dimethyl benzene-o-dicarboxylateDimethyl benzeneorthodicarboxylateEINECS 205-011-6EPA Pesticide Chemical Code 028002RCRA waste number U102Dimethylester kyseliny ftalovePhthalsaeuredimethylesterUNII-08X7F5UDJM

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 5 records
AgencyMetricValueppmmg/m3Skin
OSHATWA5 mg/m³-5N
NIOSHTWA5 mg/m³-5N
ACGIHTWA5 mg/m³ [2005]-5N
CAL/OSHATWA5 mg/m³-5N
NIOSHIDLH2000 mg/m³-2000-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 20 records
SolventFilm formerPlasticizerDeodorizerProcessing aids not otherwise specifiedFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 14 records
ListKeywordSource
inert_ingredient; non_food_use; PesticidesEPACPCat
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
Europe; nondetect; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
active_ingredient; animal_products; Europe; pharmaceutical; residueEUCPCat
detected; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
consumer_product; EuropeDanish Environmental Protection AgencyDanish EPA
consumer_product; EuropeDanish Environmental Protection AgencyDanish EPA
IFRA TransparencyIFRAIFRA
nondetect; Toys and children's productsState of Washington Department of EcologyState of Washington
air; detected; emissions; Europe; Road vehiclesDanish Environmental Protection AgencyDanish EPA
artificial_saliva; detected; emissions; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA
Canada; pharmaceuticalDrugBankDrugBank
detected; Europe; Toys and children's productsDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 100 studies
ValueUnitEndpointRouteSpeciesSource
3mg/kg---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
5%--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
9----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
10----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
12----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
13----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
15mg/kg bw/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
15mg/kg bw/day--ratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
15--oraldogUnifiedCodex:SCCS_SHADOW:beta.noael_studies
25mg/kg/d-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
33mg/kg bw/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
50----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
600----UnifiedCodex:SCCS_SHADOW:beta.noael_studies
2982mg/kg---UnifiedCodex:SCCS_SHADOW:beta.noael_studies
22.26uL/min/10^6 cellsClint-HumanNTP_ICE_adme_parameters
=66.1mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
08X7F5UDJMUNIIFDA UNII substance identifier--openFDA substances
08X7F5UDJMUNIIFDA UNII substance identifier--openFDA substances
08X7F5UDJMUNIIFDA UNII substance identifier--openFDA substances
08X7F5UDJMUNIIFDA UNII substance identifier--openFDA substances
0.656fractionFu-HumanNTP_ICE_adme_parameters
=2860mg/kg bwLD50oralRatNTP_ICE_acute_oral
=6800mg/kg bwLD50oralRatNTP_ICE_acute_oral
=3570mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=3570mg/kg bw/dayLELoralrat (sprague dawley; CD(SD)BR)ToxRefDB_ToxRefDB_v3_pod.csv
=71479.9mg/m3LELinhalationHumanToxValDB_DOE_Protective_Action_Criteria
=302mg/kg bw/dayLOAELoralRatToxValDB_PPRTV_(CPHEA)
-unitlessModel Score--NTP_ICE_endocrine
=840mg/kg bw/dayNELoralrat (sprague dawley; CD(SD)BR)ToxRefDB_ToxRefDB_v3_pod.csv
=0.000009mg/kg/dNOAELoraldogSCCS_vision_codex
=0.000009mg/kg/dNOAELoraldogSCCS_vision_codex
=0.000009mg/kg/dNOAELoraldogSCCS_vision_codex
=0.000009mg/kg/dNOAELoraldogSCCS_vision_codex
=0.00036mg/kg/dNOAELoralratSCCS_vision_codex
=0.00036mg/kg/dNOAELoralratSCCS_vision_codex
=0.00036mg/kg/dNOAELoralratSCCS_vision_codex
=0.00036mg/kg/dNOAELoralratSCCS_vision_codex
=0.00163mg/kg/dNOAELdermalratSCCS_vision_codex
=0.00163mg/kg/dNOAELdermalratSCCS_vision_codex
=0.00163mg/kg/dNOAELdermalratSCCS_vision_codex
=0.00163mg/kg/dNOAELdermalratSCCS_vision_codex
=0.00247mg/kg/dNOAELdermalhumanSCCS_vision_codex
=0.00247mg/kg/dNOAELdermalhumanSCCS_vision_codex
=0.00247mg/kg/dNOAELdermalhumanSCCS_vision_codex
=0.00247mg/kg/dNOAELdermalhumanSCCS_vision_codex
=0.006%NOAELoraldogSCCS_vision_codex
=0.006%NOAELoraldogSCCS_vision_codex
=0.006%NOAELoraldogSCCS_vision_codex
=0.006%NOAELoraldogSCCS_vision_codex
=0.0167%NOAELdermalratSCCS_vision_codex

Showing 50 of 100 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredDimethyl phthalate205-011-6ECHA overview →

EPA Toxic Release Inventory (TRI)

TRI hazard and reporting flags for the matched chemical.

SOURCE EPA Toxics Release Inventory (TRI) chemical list 1 records
ChemicalCategoryFlags
Dimethyl phthalate--

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. additional information becoming available on the adverse health effects of DMP; b. additional information or events that change the assumptions in estimating the exposures and risks of DMP in this assessment; or c. additional sources of public exposure to DMP giving rise to similar levels as those found in the cosmetic use scenario in this assessment. 2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989: a. the function or use of the chemical has changed, or is likely to change, significantly; b. the amount of the chemical being introduced has increased, or is likely to increase, significantly; c. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessment—it has begun to be manufactured in Australia; d. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment; e. additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health or the environment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvents
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL DIMETHYL PHTHALATE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
2
View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Dimethyl phthalate?

Dimethyl phthalate has 100 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.

What regulatory lists include Dimethyl phthalate?

Dimethyl phthalate appears on 12 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Indirect additives food contact (10/2018), active_ingredient; Europe; Pesticides, and 9 more. Source: EPA CPDat.

What are the occupational exposure limits for Dimethyl phthalate?

Occupational exposure limits for Dimethyl phthalate are set by OSHA, NIOSH, ACGIH. 5 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Dimethyl phthalate used in cosmetics?

Yes, Dimethyl phthalate is also indexed as a cosmetic ingredient under the name Dimethyl Phthalate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Dimethyl phthalate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, EPA Toxics Release Inventory, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Is Dimethyl phthalate used outside industrial chemicals?

Dimethyl phthalate also appears in cosmetics, pharmaceutical, cannabis databases.