NOAEL Data Cosmetic Ingredient

2,2',4,4'-Tetrahydroxybenzophenone

Also known as: BRN 1914746, EINECS 205-028-9, 2,2',4,4'-Tetrahydroxy-benzophenone, Uvinol D-50, Uvinul D-50 (+2 more)

CAS 131-55-5

2,2',4,4'-Tetrahydroxybenzophenone (CAS 131-55-5) is a chemical substance. Key regulatory status: 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Benzophenone-2 →

SOURCE noael studies public
NOAEL studies
49
SOURCE chemical inventory jurisdictions
Regulatory lists
8
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 13 fields
Name
2,2',4,4'-Tetrahydroxybenzophenone
CAS Number
131-55-5
DTXSID
DTXSID5041306
Molecular Formula
C13H10O5
InChI Key
WXNRYSGJLQFHBR-UHFFFAOYSA-N
Monoisotopic Mass
246.052823
Synonyms
BRN 1914746EINECS 205-028-92,2',4,4'-Tetrahydroxy-benzophenoneUvinol D-50Uvinul D-50UNII-PRR8K3H9VN2,2',4,4'-Hydroxybenophenone

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 22 records
UV stabilizerDeodorizerFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 8 records
ListKeywordSource
IFRA TransparencyIFRAIFRA
childrenMaine Department of Environmental ProtectionState of Maine
inert_ingredient; non_food_use; PesticidesEPACPCat
children; Europe; Personal care - specialized bath products - bath saltsDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; WA Children's Safe Product Act (4/2020)State of Washington Department of EcologyState of Washington
childrenVermont Department of HealthState of Vermont
childrenOregon Health AuthorityState of Oregon

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 49 of 49 studies
ValueUnitEndpointRouteSpeciesSource
1.75364714262133uMAC50--NTP_ICE_endocrine
5.992535597uMAC50--NTP_ICE_endocrine
1323nMAC50/EC50/IC50--NTP_ICE_endocrine
1530nMAC50/EC50/IC50--NTP_ICE_endocrine
2500nMAC50/EC50/IC50--NTP_ICE_endocrine
4900nMAC50/EC50/IC50--NTP_ICE_endocrine
62700nMAC50/EC50/IC50--NTP_ICE_endocrine
0.94227658039805uMACC--NTP_ICE_endocrine
10.53998791uMACC--NTP_ICE_endocrine
19.2uL/min/10^6 cellsClint-HumanNTP_ICE_adme_parameters
103uL/min/10^6 cellsClint-RatNTP_ICE_adme_parameters
PRR8K3H9VNUNIIFDA UNII substance identifier--openFDA substances
PRR8K3H9VNUNIIFDA UNII substance identifier--openFDA substances
PRR8K3H9VNUNIIFDA UNII substance identifier--openFDA substances
PRR8K3H9VNUNIIFDA UNII substance identifier--openFDA substances
0.0354fractionFu-HumanNTP_ICE_adme_parameters
=100mg/kg bw/dayLELoralRatToxValDB_Uterotrophic_Hershberger_DB
=185mg/kg bw/dayLELoralRatToxValDB_Uterotrophic_Hershberger_DB
=200mg/kg bw/dayLELinjectionRatToxValDB_Uterotrophic_Hershberger_DB
=229.784mg/kg bw/dayLELinjectionRatToxValDB_Uterotrophic_Hershberger_DB
=250mg/kg bw/dayLELoralRatToxValDB_Uterotrophic_Hershberger_DB
=300mg/kg bw/dayLELinjectionMouseToxValDB_Uterotrophic_Hershberger_DB
=1000mg/kg bw/dayLELoralMouseToxValDB_Uterotrophic_Hershberger_DB
200mg/kg bw/dayLOELSubcutaneousRatNTP_ICE_endocrine
229.8mg/kg bw/dayLOELSubcutaneousRatNTP_ICE_endocrine
300mg/kg bw/dayLOELSubcutaneousMouseNTP_ICE_endocrine
1000mg/kg bw/dayLOELOralMouseNTP_ICE_endocrine
-unitlessModel Score--NTP_ICE_endocrine
0.00909unitlessModel Score--NTP_ICE_endocrine
0.397unitlessModel Score--NTP_ICE_endocrine
0.448unitlessModel Score--NTP_ICE_endocrine
=5%NOAELoral-SCCS_vision_codex
=5%NOAELoral-SCCS_vision_codex
=5%NOAELoral-SCCS_vision_codex
=5%NOAELoral-SCCS_vision_codex
=7-NOAEL--SCCS_vision_codex
=7-NOAEL--SCCS_vision_codex
=7-NOAEL--SCCS_vision_codex
=7-NOAEL--SCCS_vision_codex
=620-NOAEL--SCCS_vision_codex
=620-NOAEL--SCCS_vision_codex
=620-NOAEL--SCCS_vision_codex
=620-NOAEL--SCCS_vision_codex
=1239mg/kg bw/dayNOAELoralratSCCS_vision_codex
=1239mg/kg bw/dayNOAELoralratSCCS_vision_codex
=1239mg/kg bw/dayNOAELoralratSCCS_vision_codex
=1239mg/kg bw/dayNOAELoralratSCCS_vision_codex
400mg/kg bw/dayNOELOralRatNTP_ICE_endocrine
230%Uterine weight increase vs controlSubcutaneousRatNTP_ICE_endocrine

Showing 49 of 49 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
UV Filter
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL3185091
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 2,2',4,4'-Tetrahydroxybenzophenone?

2,2',4,4'-Tetrahydroxybenzophenone has 49 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.

What regulatory lists include 2,2',4,4'-Tetrahydroxybenzophenone?

2,2',4,4'-Tetrahydroxybenzophenone appears on 6 regulatory/inventory lists including IFRA Transparency, children, inert_ingredient; non_food_use; Pesticides, and 3 more. Source: EPA CPDat.

Is 2,2',4,4'-Tetrahydroxybenzophenone used in cosmetics?

Yes, 2,2',4,4'-Tetrahydroxybenzophenone is also indexed as a cosmetic ingredient under the name Benzophenone-2. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2,2',4,4'-Tetrahydroxybenzophenone come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 2,2',4,4'-Tetrahydroxybenzophenone used outside industrial chemicals?

2,2',4,4'-Tetrahydroxybenzophenone also appears in cosmetics, pharmaceutical databases.