NOAEL Data Cosmetic Ingredient

2,2',4,4'-Tetrahydroxybenzophenone

Also known as: BRN 1914746, EINECS 205-028-9, 2,2',4,4'-Tetrahydroxy-benzophenone, Uvinol D-50, Uvinul D-50 (+2 more)

CAS 131-55-5

2,2',4,4'-Tetrahydroxybenzophenone (CAS 131-55-5) is a chemical substance. Key regulatory status: 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Benzophenone-2 →

SOURCE NOAEL studies
NOAEL studies
34
SOURCE Chemical inventory jurisdictions
Regulatory lists
8
SOURCE EU CLP Annex VI
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 12 fields
Name
2,2',4,4'-Tetrahydroxybenzophenone
CAS Number
131-55-5
Molecular Formula
C13H10O5
InChI Key
WXNRYSGJLQFHBR-UHFFFAOYSA-N
Monoisotopic Mass
246.052823
Synonyms
BRN 1914746EINECS 205-028-92,2',4,4'-Tetrahydroxy-benzophenoneUvinol D-50Uvinul D-50UNII-PRR8K3H9VN2,2',4,4'-Hydroxybenophenone

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 22 records
UV stabilizerDeodorizerFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 8 records
ListKeywordSource
IFRA TransparencyIFRAIFRA
childrenMaine Department of Environmental ProtectionState of Maine
inert_ingredient; non_food_use; PesticidesEPACPCat
children; Europe; Personal care - specialized bath products - bath saltsDanish Environmental Protection AgencyDanish EPA
children; Europe; Personal careDanish Environmental Protection AgencyDanish EPA
children; WA Children's Safe Product Act (4/2020)State of Washington Department of EcologyState of Washington
childrenVermont Department of HealthState of Vermont
childrenOregon Health AuthorityState of Oregon

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 34 of 34 studies
ValueUnitEndpointRouteSpeciesSource
1.754uMAC50--NTP ICE endocrine
5.993uMAC50--NTP ICE endocrine
1323nMAC50/EC50/IC50--NTP ICE endocrine
1530nMAC50/EC50/IC50--NTP ICE endocrine
2500nMAC50/EC50/IC50--NTP ICE endocrine
4900nMAC50/EC50/IC50--NTP ICE endocrine
6.270e+4nMAC50/EC50/IC50--NTP ICE endocrine
0.9423uMACC--NTP ICE endocrine
10.54uMACC--NTP ICE endocrine
19.2uL/min/10^6 cellsClint-HumanNTP ICE adme parameters
103uL/min/10^6 cellsClint-RatNTP ICE adme parameters
PRR8K3H9VNUNIIFDA UNII substance identifier--openFDA substances
0.0354fractionFu-HumanNTP ICE adme parameters
=100mg/kg bw/dayLELoralRatToxValDB Uterotrophic Hershberger DB
=185mg/kg bw/dayLELoralRatToxValDB Uterotrophic Hershberger DB
=200mg/kg bw/dayLELinjectionRatToxValDB Uterotrophic Hershberger DB
=229.8mg/kg bw/dayLELinjectionRatToxValDB Uterotrophic Hershberger DB
=250mg/kg bw/dayLELoralRatToxValDB Uterotrophic Hershberger DB
=300mg/kg bw/dayLELinjectionMouseToxValDB Uterotrophic Hershberger DB
=1000mg/kg bw/dayLELoralMouseToxValDB Uterotrophic Hershberger DB
200mg/kg bw/dayLOELSubcutaneousRatNTP ICE endocrine
229.8mg/kg bw/dayLOELSubcutaneousRatNTP ICE endocrine
300mg/kg bw/dayLOELSubcutaneousMouseNTP ICE endocrine
1000mg/kg bw/dayLOELOralMouseNTP ICE endocrine
0unitlessModel Score--NTP ICE endocrine
0.00909unitlessModel Score--NTP ICE endocrine
0.397unitlessModel Score--NTP ICE endocrine
0.448unitlessModel Score--NTP ICE endocrine
=5%NOAELoral-SCCS Opinion
=7-NOAEL--SCCS Opinion
=620-NOAEL--SCCS Opinion
=1239mg/kg bw/dayNOAELoralratSCCS Opinion
400mg/kg bw/dayNOELOralRatNTP ICE endocrine
230%Uterine weight increase vs controlSubcutaneousRatNTP ICE endocrine

Showing 34 of 34 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
UV Filter
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed CHEMBL3185091
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 2,2',4,4'-Tetrahydroxybenzophenone?

2,2',4,4'-Tetrahydroxybenzophenone has 34 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.

What regulatory lists include 2,2',4,4'-Tetrahydroxybenzophenone?

2,2',4,4'-Tetrahydroxybenzophenone appears on 6 regulatory/inventory lists including IFRA Transparency, children, inert_ingredient; non_food_use; Pesticides, and 3 more. Source: EPA CPDat.

Is 2,2',4,4'-Tetrahydroxybenzophenone used in cosmetics?

Yes, 2,2',4,4'-Tetrahydroxybenzophenone is also indexed as a cosmetic ingredient under the name Benzophenone-2. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2,2',4,4'-Tetrahydroxybenzophenone come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 2,2',4,4'-Tetrahydroxybenzophenone used outside industrial chemicals?

2,2',4,4'-Tetrahydroxybenzophenone also appears in cosmetics, pharmaceutical databases.