Also known as: BRN 1914746, EINECS 205-028-9, 2,2',4,4'-Tetrahydroxy-benzophenone, Uvinol D-50, Uvinul D-50 (+2 more)
INCI: BENZOPHENONE-2
Benzophenone-2 (CAS 131-55-5) is a cosmetic cosmetic ingredient functioning as UV filter, light stabilizer, fragrance. Reported NOAEL =1239 mg/kg bw/day in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: permitted; 3 safety opinions reviewed (sccs). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 131-55-5 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for Benzophenone-2.
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4 study endpoints found for Benzophenone-2. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1239 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =1239 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =1239 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =1239 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
g the potential endocrine disrupting properties, the SCCS is of the opinion that BP-5 is safe when used as a UV filter up to a maximum concentration of 5% in sunscreen, face and hand cream, lipstick, sunscreen propellant spray and pump spray, when used separately or in combination (based on
g the potential endocrine disrupting properties, the SCCS is of the opinion that BP-5 is safe when used as a UV filter up to a maximum concentration of 5% in sunscreen, face and hand cream, lipstick, sunscreen propellant spray and pump spray, when used separately or in combination (based on
g the potential endocrine disrupting properties, the SCCS is of the opinion that BP-5 is safe when used as a UV filter up to a maximum concentration of 5% in sunscreen, face and hand cream, lipstick, sunscreen propellant spray and pump spray, when used separately or in combination (based on
9 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | =1220 mg/kg | Rat | oral | - | ChemIDplus |
| LEL | =185 mg/kg-day | Rat | oral | subchronic | Uterotrophic Hershberger DB |
| LEL | =100 mg/kg-day | Rat | oral | short-term | Uterotrophic Hershberger DB |
| LEL | =100 mg/kg-day | Rat | injection | short-term | Uterotrophic Hershberger DB |
| LEL | =200 mg/kg-day | Rat | injection | short-term | Uterotrophic Hershberger DB |
| LEL | =250 mg/kg-day | Rat | oral | short-term | Uterotrophic Hershberger DB |
| LEL | =300 mg/kg-day | Mouse | injection | short-term | Uterotrophic Hershberger DB |
| LEL | =1000 mg/kg-day | Mouse | oral | short-term | Uterotrophic Hershberger DB |
| LEL | =229.784 mg/kg-day | Rat | injection | short-term | Uterotrophic Hershberger DB |
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Source list: II
agonist (ERα, ERβ); antagonist (AR)
| Endpoint | Target | Value | Direction |
|---|---|---|---|
| EC50_ER | ERα | 0.30 µM | agonist |
| IC50_AR | AR | 1.53 µM | antagonist |
| EC_threshold_ER | ERα | 10⁻⁴ to 10⁻⁷ M M | agonist |
| ERE luciferase + cell number | ERa | EC50/IC50: Active >=10^-7 M (ERE-Luc); Active >=10^-6 M (proliferation); LOEC: 0.1 uM (ERE-Luc); NOEC: 0.01 uM mixed | agonist |
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| JP | restricted | Wash-away: 10% | Leave-on: 10% | Mucosa: 0.050% | Wash-away: 10% | Leave-on: 10% | Mucosa: 0.050% |
2 property records from structured ingredient metadata.
Expert safety assessment and concern-level summary for Benzophenone-2.
Public NOAEL study rows linked to Benzophenone-2 by CAS number or substance name.
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Benzophenone-2 has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.
Benzophenone-2 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Benzophenone-2 functions as: UV filter, light stabilizer, fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 131-55-5.
The NOAEL (No Observed Adverse Effect Level) for Benzophenone-2 is =1239 mg/kg bw/day based on a repeated dose toxicity study via oral route in rat. A total of 4 study endpoints are available. Source: SCCS_vision_codex.
Benzophenone-2 also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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