Warning GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

Manganese dioxide

Also known as: Manganese Dioxide (Mn02 ), MnO2, Manganese oxide (MnO2), C.I. Pigment Black 14, C.I. Pigment Brown 8 (+13 more)

CAS 1313-13-9

Manganese dioxide (CAS 1313-13-9) is a chemical substance with GHS signal word Warning; key hazard signal: H332; H302. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Manganese Dioxide →

SOURCE noael studies public
NOAEL studies
5
SOURCE chemical inventory jurisdictions
Regulatory lists
2
SOURCE eu clp annex vi
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 24 fields
Name
Manganese dioxide
CAS Number
1313-13-9
DTXSID
DTXSID6042109
Molecular Formula
Mn.2O
InChI Key
GOPYZMJAIPBUGX-UHFFFAOYSA-N
Monoisotopic Mass
86.927873
Synonyms
Manganese Dioxide (Mn02 )MnO2Manganese oxide (MnO2)C.I. Pigment Black 14C.I. Pigment Brown 8Black manganese oxideBOG manganeseCement BlackEINECS 215-202-6Manganese binoxideManganese BlackManganese superoxide

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 4 *; Acute Tox. 4 *H332; H302GHS07Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
Short-term EffectsThe aerosol is irritating to the respiratory tract.
Long-term EffectsThe substance may have effects on the lungs and central nervous system. This may result in increased susceptibility to bronchitis, pneumonitis and neurologic and neuropsychiatric disorders (manganism). Animal tests show that this substance possibly causes toxicity to human reproduction or development.
Routes of ExposureThe substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 5 records
AntioxidantPigment

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records
ListKeywordSource
Canada; consumer_product; Substances in Products - Canada (4/2014)Government of CanadaCPCat
inert_ingredient; non_food_use; PesticidesEPACPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 5 of 5 studies
ValueUnitEndpointRouteSpeciesSource
=0.2mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
TF219GU161UNIIFDA UNII substance identifier--openFDA substances
TF219GU161UNIIFDA UNII substance identifier--openFDA substances
TF219GU161UNIIFDA UNII substance identifier--openFDA substances
TF219GU161UNIIFDA UNII substance identifier--openFDA substances

Showing 5 of 5 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredManganese dioxide215-202-6ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
View full cosmetic safety profile →

Frequently Asked Questions

What is the GHS hazard classification for Manganese dioxide?

Manganese dioxide (CAS 1313-13-9) is classified under EU CLP Annex VI as Acute Tox. 4 *; Acute Tox. 4 * with signal word Warning. Hazard statements: H332; H302. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Manganese dioxide?

Manganese dioxide has 5 NOAEL studies in the database. The lowest reported value is 0.2 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Manganese dioxide?

Manganese dioxide appears on 2 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.

Is Manganese dioxide used in cosmetics?

Yes, Manganese dioxide is also indexed as a cosmetic ingredient under the name Manganese Dioxide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Manganese dioxide come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is Manganese dioxide used outside industrial chemicals?

Manganese dioxide also appears in cosmetics databases.