Is Manganese Dioxide safe in cosmetics?
Manganese Dioxide has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Manganese Dioxide
Also known as: Manganese Dioxide (Mn02 ), MnO2, Manganese oxide (MnO2), C.I. Pigment Black 14, C.I. Pigment Brown 8 (+13 more)
INCI: MANGANESE DIOXIDE
Manganese Dioxide (CAS 1313-13-9) is a cosmetic cosmetic ingredient functioning as Antioxidant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 1313-13-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Manganese Dioxide is classified GHS Danger (H302, H332, H372, H370) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antioxidant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
dioxomanganese
InChIKey
NUJOXMJBOLGQSY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed - not specifically prohibited or restricted for cosmetic use; not an FDA-approved color additive
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Manganese Dioxide.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The aerosol is irritating to the respiratory tract.
Long-term Exposure Effects
The substance may have effects on the lungs and central nervous system. This may result in increased susceptibility to bronchitis, pneumonitis and neurologic and neuropsychiatric disorders (manganism). Animal tests show that this substance possibly causes toxicity to human reproduction or development.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Acute Tox. 4 *; Acute Tox. 4 *
Hazard Statements
- H332 Harmful if inhaled
- H302 Harmful if swallowed
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| ASEAN | permitted_colorant | - | Not mucous membranes |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
ICSC Safety Card
0175
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Pigment
Expert Verdict
Expert safety assessment and concern-level summary for Manganese Dioxide.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Manganese Dioxide by CAS number or substance name.
Studies
12
Lowest NOAEL
2 mg/kg bw/day
Highest NOAEL
2000 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Manganese Dioxide (Mn02 )
MnO2
Manganese oxide (MnO2)
C.I. Pigment Black 14
C.I. Pigment Brown 8
Black manganese oxide
BOG manganese
Cement Black
EINECS 215-202-6
Manganese binoxide
Manganese Black
Manganese superoxide
Pyrolusite Brown
Braunstein
Bruinsteen
Mangaanbioxyde
Mangaandioxyde
UNII-TF219GU161
Chemical Function
Antioxidant
Pigment
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Manganese Dioxide allowed in the EU?
Manganese Dioxide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Manganese Dioxide do in cosmetics?
Manganese Dioxide functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 1313-13-9.
Is Manganese Dioxide used outside cosmetics?
Manganese Dioxide also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Manganese Dioxide have different safety status in cosmetics vs industrial chemicals?
Manganese Dioxide is classified GHS Danger (H302, H332, H372, H370) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Manganese Dioxide compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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