Also known as: UNII-5LIV96LADQ, 2-Chloro-6-(ethylamino)-4-nitrophenol, 6-Chloro-2-(ethylamino)-4-nitrophenol, Phenol, 2-chloro-6-(ethylamino)-4-nitro-
CAS 131657-78-8
2-Chloro-6-ethylamino-4-nitrophenol (CAS 131657-78-8) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H317; H411. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
View cosmetic safety profile for 2-Chloro-6-Ethylamino-4-Nitrophenol →
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Skin Sens. 1; Aquatic Chronic 2 | H302; H317; H411 | GHS07; GHS09 | Warning |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| Europe; Personal care; restricted | European Commission | CosIng |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 10 | mg/kg bw | - | - | rat | Regulatory source |
| 5LIV96LADQ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 10 | mg/kg bw/day | LOAEL | oral | rat | COSMOS DB |
| =10 | mg/kg bw | NOAEL | - | rat | SCCS Opinion |
| =10 | mg/kg | NOAEL | oral | rat | SCCS Opinion |
| =90 | mg/kg bw | NOAEL | - | rat | SCCS Opinion |
| 10 | mg/kg bw | dermal absorption | - | rat | Regulatory source |
| =10 | mg/kg | dermal absorption | oral | rat | Regulatory source |
| 90 | mg/kg bw | dermal absorption | - | rat | Regulatory source |
| 10 | mg/kg bw | developmental toxicity | oral | rat | Regulatory source |
| 90 | mg/kg bw | developmental toxicity | - | rat | Regulatory source |
| 90 | mg/kg bw | developmental toxicity | dermal | rat | Regulatory source |
Showing 12 of 12 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-chloro-6-(ethylamino)-4-nitrophenol | 411-440-1 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
EU Scientific Committee opinions tied to the matched substance.
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/1114/07 | 18 December 2007 | safe | 3.0% | secondary amine; nitrosamine <50ppb; sensitisation not excluded |
| SCCP/1090/07 | 18 December 2007 | The SCCP is of the opinion that the use of 2-chloro-6-ethylamino-4-nitrophenol, at a maximum on-head concentration of 1.5% in oxidative hair dye formulations and at a maximum on-head concentration of 3.0% in non-oxidative hair dye formulations, does not pose a risk to the health of the consumer, apart from its sensitising potential. | 1.5% on-head (oxidative); 3.0% on-head (non-oxidative) | Sensitising potential; no batch characterisation/composition documentation provided; secondary amine prone to nitrosation (do not use with nitrosating substances, nitrosamine < 50 ppb, content not reported); finished-formulation genotoxicity studies needed. |
Same-CAS cosmetic ingredient record for cross-vertical context.
2-Chloro-6-ethylamino-4-nitrophenol (CAS 131657-78-8) is classified under EU CLP Annex VI as Acute Tox. 4 *; Skin Sens. 1; Aquatic Chronic 2 with signal word Warning. Hazard statements: H302; H317; H411. Source: EU CLP Annex VI (ECHA).
2-Chloro-6-ethylamino-4-nitrophenol has 12 NOAEL studies in the database. The lowest reported value is 10 mg/kg bw in rat. Source: Regulatory source.
2-Chloro-6-ethylamino-4-nitrophenol appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.
Yes, 2-Chloro-6-ethylamino-4-nitrophenol is also indexed as a cosmetic ingredient under the name 2-Chloro-6-Ethylamino-4-Nitrophenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
2-Chloro-6-ethylamino-4-nitrophenol also appears in cosmetics databases.