Also known as: UNII-5LIV96LADQ, 2-Chloro-6-(ethylamino)-4-nitrophenol, 6-Chloro-2-(ethylamino)-4-nitrophenol, Phenol, 2-chloro-6-(ethylamino)-4-nitro-
INCI: 2-CHLORO-6-ETHYLAMINO-4-NITROPHENOL
2-Chloro-6-Ethylamino-4-Nitrophenol (CAS 131657-78-8) is a cosmetic cosmetic ingredient functioning as Hair dyeing (oxidative and non-oxidative/semi-permanent dyes). Reported NOAEL =10 mg/kg bw in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: restricted, max 3.0%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 131657-78-8 →
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Chloro-6-Ethylamino-4-Nitrophenol.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for 2-Chloro-6-Ethylamino-4-Nitrophenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =10 mg/kg bw | - | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =10 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =10 mg/kg bw | - | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =10 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =10 mg/kg bw | - | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =10 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =10 mg/kg bw | - | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =10 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =90 mg/kg bw | - | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =90 mg/kg bw | - | rat | dermal absorption | SCCS_vision_codex |
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Inserted via ATP: CLP00
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.14% | - | - | SCCP/0118 |
| measured | 3.0% | - | - | SCCP/0118 |
| measured | 0.1% | in_vivo | - | SCCP/0118 |
| measured | 1.36% | - | - | SCCP/0118 |
| measured | 1.6% | - | - | SCCP/0118 |
1 property record from structured ingredient metadata.
Expert safety assessment and concern-level summary for 2-Chloro-6-Ethylamino-4-Nitrophenol.
Public NOAEL study rows linked to 2-Chloro-6-Ethylamino-4-Nitrophenol by CAS number or substance name.
Units vary across source rows: mg/kg bw, mg/kg
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.14% | - | - |
| 3.0% | - | - |
| 0.1% | in_vivo | - |
| 1.36% | - | - |
| 1.6% | - | - |
2-Chloro-6-Ethylamino-4-Nitrophenol has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
2-Chloro-6-Ethylamino-4-Nitrophenol EU regulatory status: restricted. Maximum allowed concentration: 3.0%. This is based on EU Regulation 1223/2009 and its amendments.
2-Chloro-6-Ethylamino-4-Nitrophenol functions as: Hair dyeing (oxidative and non-oxidative/semi-permanent dyes). It is classified as a cosmetic ingredient in our database. CAS number: 131657-78-8.
The NOAEL (No Observed Adverse Effect Level) for 2-Chloro-6-Ethylamino-4-Nitrophenol is =10 mg/kg bw based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
2-Chloro-6-Ethylamino-4-Nitrophenol also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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