2-Chloro-6-Ethylamino-4-Nitrophenol
INCI: 2-CHLORO-6-ETHYLAMINO-4-NITROPHENOL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for 2-Chloro-6-Ethylamino-4-Nitrophenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 10 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Restricted under Annex III at 3.0% maximum concentration for hair dyes. Mandatory allergic reaction warning required; not permitted for eyelash or eyebrow use. FDA permits with coal-tar dye exemption provisions.
Regulatory Flags
Frequently Asked Questions
Is 2-Chloro-6-Ethylamino-4-Nitrophenol safe in cosmetics?
Restricted under Annex III at 3.0% maximum concentration for hair dyes. Mandatory allergic reaction warning required; not permitted for eyelash or eyebrow use. FDA permits with coal-tar dye exemption provisions. The EU classifies 2-Chloro-6-Ethylamino-4-Nitrophenol as "restricted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is 2-Chloro-6-Ethylamino-4-Nitrophenol allowed in the EU?
2-Chloro-6-Ethylamino-4-Nitrophenol EU regulatory status: restricted. Maximum allowed concentration: 3.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Chloro-6-Ethylamino-4-Nitrophenol do in cosmetics?
2-Chloro-6-Ethylamino-4-Nitrophenol functions as: Hair dyeing (oxidative and non-oxidative/semi-permanent dyes). It is classified as a cosmetic ingredient in our database. CAS number: 131657-78-8.
What is the Margin of Safety for 2-Chloro-6-Ethylamino-4-Nitrophenol?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 2-Chloro-6-Ethylamino-4-Nitrophenol?
The NOAEL (No Observed Adverse Effect Level) for 2-Chloro-6-Ethylamino-4-Nitrophenol is 10 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.
Compliance Tools
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