Also known as: 2-Biphenylol, sodium salt, [1,1'-Biphenyl]-2-ol, sodium salt, o-Phenylphenol, sodium salt, [1,1'-Biphenyl]-2-ol, sodium salt (1:1), Sodium orthophenylphenoxide (+15 more)
CAS 132-27-4
Sodium 2-phenylphenate (CAS 132-27-4) is a chemical substance with GHS signal word Danger; key hazard signal: H302; H335; H315; H318; H400. Key regulatory status: California Proposition 65, REACH registered, 24 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65, EPA TRI.
Sodium 2-phenylphenate is classified GHS Danger (H302, H335, H315, H318, H400) in the chemicals database but is allowed in EU cosmetics at max 0.2%.
CAS, identifiers, formula, and alternate names for the matched substance record.
Carcinogenic hazard classification from IARC monograph evaluations.
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 1998 | Sup 7, 73 |
California OEHHA listing status and toxicity category.
| Chemical | Toxicity Type | Cancer | Developmental | Listed |
|---|---|---|---|---|
| - | cancer | Yes | No | - |
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Dam. 1; Aquatic Acute 1 | H302; H335; H315; H318; H400 | GHS07; GHS05; GHS09 | Danger |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| OEHHA Proposition 65 (3/2019) | STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY | OEHHA Proposition 65 List |
| OEHHA Proposition 65 (1/2023) | California Office of Environmental Health Hazard Assessment | OEHHA Proposition 65 List |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=0.2 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| AB200 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| AB200 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| AB200 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| AB200 | ug/day | California Proposition 65 NSRL | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| ABcancer | listing type | California Proposition 65 listing | - | - | California Proposition 65 |
| =19.25 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| KFV9K7N7UI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| KFV9K7N7UI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| KFV9K7N7UI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| KFV9K7N7UI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP_ICE_cancer |
| =656 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =2 | % diet | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =2 | % | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =100 | mg/kg bw/day | LOEL | oral | Mouse | ToxValDB_ECOTOX |
| =10 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB_ECOTOX |
Showing 23 of 23 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sodium 2-biphenylate | 205-055-6 | ECHA overview → |
TRI hazard and reporting flags for the matched chemical.
| Chemical | Category | Flags |
|---|---|---|
| Sodium o-phenylphenoxide | - | - |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS food additive, ADI, and GRAS records where available.
E232 — ADI: 0.2 mg/kg bw
View full food safety profile →Sodium 2-phenylphenate (CAS 132-27-4) is classified under EU CLP Annex VI as Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Dam. 1; Aquatic Acute 1 with signal word Danger. Hazard statements: H302; H335; H315; H318; H400. Source: EU CLP Annex VI (ECHA).
Sodium 2-phenylphenate has 23 NOAEL studies in the database. The lowest reported value is 0.2 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
Sodium 2-phenylphenate appears on 7 regulatory/inventory lists including OEHHA Proposition 65 (3/2019), OEHHA Proposition 65 (1/2023), active_ingredient; Pesticides, and 4 more. Source: EPA CPDat.
Sodium 2-phenylphenate is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Yes, Sodium 2-phenylphenate is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.
Yes, Sodium 2-phenylphenate is also indexed as a cosmetic ingredient under the name Sodium o-Phenylphenate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, EPA Toxics Release Inventory, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Sodium 2-phenylphenate is classified GHS Danger (H302, H335, H315, H318, H400) in the chemicals database but is allowed in EU cosmetics at max 0.2%.
Sodium 2-phenylphenate also appears in cosmetics, food safety databases.