Sodium o-Phenylphenate
INCI: SODIUM O-PHENYLPHENATE (SODIUM 2-BIPHENYLOLATE)
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Sodium o-Phenylphenate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=300 mg/kg bw/day | oral | dog | oral | REACH |
| NOAEL | >=1000 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOAEL | >=1000 mg/kg bw/day | dermal | - | dermal | REACH |
| NOAEL | 39 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=300 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | 39 mg/kg bw/day | oral | - | oral | REACH |
Expert Verdict
🚨 HIGH ALERT: RAC proposed Carcinogen Category 2 classification (Dec 2022); OPP salts already removed from EU authorized preservative list; SCCS published final opinion; Article 15(1) Cosmetics Regulation triggers prohibition for Cat. 2 CMR substances unless SCCS finds safe
Regulatory Flags
Frequently Asked Questions
Is Sodium o-Phenylphenate safe in cosmetics?
🚨 HIGH ALERT: RAC proposed Carcinogen Category 2 classification (Dec 2022); OPP salts already removed from EU authorized preservative list; SCCS published final opinion; Article 15(1) Cosmetics Regulation triggers prohibition for Cat. 2 CMR substances unless SCCS finds safe The EU classifies Sodium o-Phenylphenate as "permitted". Safety rating: POOR. 6 toxicological study endpoint(s) are available in our database.
Is Sodium o-Phenylphenate allowed in the EU?
Sodium o-Phenylphenate EU regulatory status: permitted. Maximum allowed concentration: 0.2%. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium o-Phenylphenate do in cosmetics?
Sodium o-Phenylphenate functions as: Preservative. It is classified as a cosmetic ingredient in our database. CAS number: 132-27-4.
What is the Margin of Safety for Sodium o-Phenylphenate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Sodium o-Phenylphenate?
The NOAEL (No Observed Adverse Effect Level) for Sodium o-Phenylphenate is >=300 mg/kg bw/day based on a oral study via oral route in dog. A total of 6 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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