NOAEL Data REACH Registered Cosmetic Ingredient

Tris(methylphenyl) phosphate

Also known as: Tritolyl phosphate, Phosphoric acid, tris(methylphenyl) ester, Caswell No. 884, EINECS 215-548-8, EPA Pesticide Chemical Code 083401 (+13 more)

CAS 1330-78-5

Tris(methylphenyl) phosphate (CAS 1330-78-5) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Tricresyl Phosphate →

Cross-Vertical Regulatory Divergence

Tris(methylphenyl) phosphate is prohibited in EU cosmetics but has active industrial GHS classifications (H361, H400, H410).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 20 fields

Name

Tris(methylphenyl) phosphate

CAS Number

1330-78-5

Synonyms

Tritolyl phosphatePhosphoric acid, tris(methylphenyl) esterCaswell No. 884EINECS 215-548-8EPA Pesticide Chemical Code 083401Flexol Plasticizer TCPNCI-C61041Phosflex 179AThiorthocresyl phosphatePhosphate de tricresyleTricresilfosfatiTricresylfosfaten

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 15 records

PlasticizerFlame retardant

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 6 records

List	Keyword	Source
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
active_ingredient; Pesticides	MN Department of Agriculture Pesticide Sales Database	CPCat
banned; Europe; Personal care	European Commission	CosIng
children	Vermont Department of Health	State of Vermont
children; WA Children's Safe Product Act (4/2020)	State of Washington Department of Ecology	State of Washington

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 36 of 36 studies

Value	Unit	Endpoint	Route	Species	Source
41.69	uM	AC50	-	-	NTP ICE endocrine
95.44	uM	ACC	-	-	NTP ICE endocrine
=2.12	mg/kg bw/day	BMDL (10)	oral	Rat	ToxValDB ATSDR MRLs
=3.72	mg/kg bw/day	BMDL (10)	oral	Rat	ToxValDB ATSDR MRLs
=0.18	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
512641US16	UNII	FDA UNII substance identifier	-	-	openFDA substances
=7	mg/kg bw/day	LEL	oral	Mouse	ToxValDB ToxRefDB
=7	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	EPA ToxRefDB v3
=8	mg/kg bw/day	LEL	oral	Mouse	ToxValDB ToxRefDB
=8	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	EPA ToxRefDB v3
=0.5	% diet	LOAEL	oral	Rat	ToxValDB HPVIS
=20	mg/kg bw/day	LOAEL	oral	Rat	ECHA
=62.5	mg/kg bw/day	LOAEL	oral	Mouse	ECHA
=2000	ppm	LOEL	oral	Mouse	ToxValDB ECOTOX
=0.02	mg/kg bw/day	MRL	oral	Human	ToxValDB ATSDR MRLs
=0.04	mg/kg bw/day	MRL	oral	Human	ToxValDB ATSDR MRLs
0	unitless	Model Score	-	-	NTP ICE endocrine
0.0171	unitless	Model Score	-	-	NTP ICE endocrine
>0	mg/kg bw/day	NEL	oral	mouse (b6c3f1; B6C3F1)	EPA ToxRefDB v3
=1000	mg/m3	NEL	inhalation	Rat	ToxValDB EPA TSCA 8e
=0.1	% diet	NOAEL	oral	Rat	ToxValDB HPVIS
=200	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB HESS
=300	mg/m3	NOAEL	inhalation	Rat	ECHA
=1000	mg/m3	NOAEL	inhalation	Rat	ECHA
=1000	mg/kg bw/day	NOAEL	oral	Rat	ECHA
=2000	mg/kg bw/day	NOAEL	oral	Chicken	ECHA
=0.1	%	NOEL	oral	Mouse	ToxValDB ECOTOX
=0.1	mg/L	NOEL	-	-	WHO/JECFA
=0.2	%	NOEL	oral	Mouse	ToxValDB ECOTOX
=30	mg/kg bw/day	NOEL	oral	Rat	ECHA
<40	mg/kg bw/day	NOEL	oral	Rat	ToxValDB HESS
<50	mg/kg bw/day	NOEL	oral	Rat	ToxValDB HESS
=65	mg/kg bw/day	NOEL	oral	Rat	ToxValDB HESS
<86.4	mg/kg bw/day	NOEL	oral	Rat	ToxValDB HESS
250	ppm	Top dose	Gavage; Dosed feed	Mouse	NTP ICE cancer
600	ppm	Top dose	Gavage; Dosed feed	Rat	NTP ICE cancer

Showing 36 of 36 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Tris(methylphenyl) phosphate	809-930-9	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Frequently Asked Questions

What is the NOAEL for Tris(methylphenyl) phosphate?

Tris(methylphenyl) phosphate has 36 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP ICE endocrine.

What regulatory lists include Tris(methylphenyl) phosphate?

Tris(methylphenyl) phosphate appears on 4 regulatory/inventory lists including active_ingredient; Pesticides, banned; Europe; Personal care, children, and 1 more. Source: EPA CPDat.

Is Tris(methylphenyl) phosphate used in cosmetics?

Yes, Tris(methylphenyl) phosphate is also indexed as a cosmetic ingredient under the name Tricresyl Phosphate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Tris(methylphenyl) phosphate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does Tris(methylphenyl) phosphate have different safety status in cosmetics vs industrial chemicals?

Tris(methylphenyl) phosphate is prohibited in EU cosmetics but has active industrial GHS classifications (H361, H400, H410).

Is Tris(methylphenyl) phosphate used outside industrial chemicals?

Tris(methylphenyl) phosphate also appears in cosmetics databases.