Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Tricresyl Phosphate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 50 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 250 ppm | oral | rat | oral | REACH |
| NOAEL | 900 ppm | oral | rat | oral | REACH |
| NOAEL | 50 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 0.1 other | oral | rat | oral | REACH |
| NOAEL | 360 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 360 mg/kg bw/day | oral | mouse | oral | REACH |
Expert Verdict
🚫 BANNED SUBSTANCE. Potent neurotoxin causing OPIDN (organophosphate-induced delayed neuropathy); not PBT but assessed under CoRAP; absolutely cannot be used in any cosmetic product
Regulatory Flags
Frequently Asked Questions
Is Tricresyl Phosphate safe in cosmetics?
🚫 BANNED SUBSTANCE. Potent neurotoxin causing OPIDN (organophosphate-induced delayed neuropathy); not PBT but assessed under CoRAP; absolutely cannot be used in any cosmetic product The EU classifies Tricresyl Phosphate as "prohibited". Safety rating: POOR. 8 toxicological study endpoint(s) are available in our database.
Is Tricresyl Phosphate allowed in the EU?
Tricresyl Phosphate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Tricresyl Phosphate do in cosmetics?
Tricresyl Phosphate functions as: Plasticizer (industrial chemical, not a cosmetic function). It is classified as a cosmetic ingredient in our database. CAS number: 1330-78-5.
What is the Margin of Safety for Tricresyl Phosphate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Tricresyl Phosphate?
The NOAEL (No Observed Adverse Effect Level) for Tricresyl Phosphate is 50 mg/kg bw/day based on a oral study via oral route in rat. A total of 8 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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