Is Tricresyl Phosphate safe in cosmetics?
Tricresyl Phosphate has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Tricresyl Phosphate
Also known as: Tritolyl phosphate, Phosphoric acid, tris(methylphenyl) ester, Caswell No. 884, EINECS 215-548-8, EPA Pesticide Chemical Code 083401 (+13 more)
INCI: TRICRESYL PHOSPHATE
Tricresyl Phosphate (CAS 1330-78-5) is a cosmetic cosmetic ingredient functioning as Plasticizer (industrial chemical, not a cosmetic function). NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 1330-78-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Tricresyl Phosphate is prohibited in EU cosmetics but has active industrial GHS classifications (H361, H400, H410).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Plasticizer (industrial chemical, not a cosmetic function)
Safety Rating
POOR
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not approved for cosmetic use; neurotoxic industrial chemical
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tricresyl Phosphate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Tricresyl Phosphate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =2000 mg/kg bw/day | oral | Chicken | repeat dose other | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Tricresyl Phosphate across SCCS product categories, with measured dermal absorption where available.
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Suspected
Evidence: Limited
(2020)
Health effects: Yes
Affected pathways: Thyroid, Anti-androgenic
Source list: III
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 277
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CA | banned | - | - |
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flame retardant
Plasticizer
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Tricresyl Phosphate.
Regulatory Flags
eu_banned_cosmetics
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Tricresyl Phosphate by CAS number or substance name.
Studies
1
Lowest NOAEL
2000 mg/kg bw/day
Highest NOAEL
2000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Tritolyl phosphate
Phosphoric acid, tris(methylphenyl) ester
Caswell No. 884
EINECS 215-548-8
EPA Pesticide Chemical Code 083401
Flexol Plasticizer TCP
NCI-C61041
Phosflex 179A
Thiorthocresyl phosphate
Phosphate de tricresyle
Tricresilfosfati
Tricresylfosfaten
Trikresylfosfat
Trikresylphosphate
Tritolylfosfat
UNII-512641US16
TCP
TMPP
Chemical Function
Plasticizer
Flame retardant
Regulatory Lists
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
banned; Europe; Personal care
children
children; WA Children's Safe Product Act (4/2020)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Tricresyl Phosphate allowed in the EU?
Tricresyl Phosphate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Tricresyl Phosphate do in cosmetics?
Tricresyl Phosphate functions as: Plasticizer (industrial chemical, not a cosmetic function). It is classified as a cosmetic ingredient in our database. CAS number: 1330-78-5.
What is the NOAEL for Tricresyl Phosphate?
The NOAEL (No Observed Adverse Effect Level) for Tricresyl Phosphate is =2000 mg/kg bw/day based on a repeat dose other study via oral route in Chicken. Source: ToxValDB_ECHA_IUCLID.
Is Tricresyl Phosphate used outside cosmetics?
Tricresyl Phosphate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Tricresyl Phosphate have different safety status in cosmetics vs industrial chemicals?
Tricresyl Phosphate is prohibited in EU cosmetics but has active industrial GHS classifications (H361, H400, H410).
Compliance Tools
Check Tricresyl Phosphate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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