NOAEL Data REACH Registered Cosmetic Ingredient

2-Butanone peroxide

Also known as: Methyl ethyl ketone peroxide, Chaloxyd MEKP HA 1, EINECS 215-661-2, Esperfoam FR, HI-Point PD-1 (+9 more)

CAS 1338-23-4

2-Butanone peroxide (CAS 1338-23-4) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for MEK Peroxides (Methyl Ethyl Ketone Peroxide / MEKP) →

Cross-Vertical Regulatory Divergence

2-Butanone peroxide is classified GHS Danger (H242, H302, H314, H318, H332, H312, H335, H341) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 20 fields

Name

2-Butanone peroxide

CAS Number

1338-23-4

DTXSID

DTXSID1024671

Molecular Formula

C8H18O6

InChI Key

WFUGQJXVXHBTEM-UHFFFAOYSA-N

Monoisotopic Mass

210.110338

Synonyms

Methyl ethyl ketone peroxideChaloxyd MEKP HA 1EINECS 215-661-2Esperfoam FRHI-Point PD-1Lupersol DELMethylethylketonhydroperoxideNCI-C55447Quickset ExtraQuickset superRCRA waste number U160Sprayset MEKP

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
Short-term Effects	The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion.
Routes of Exposure	The substance can be absorbed into the body by inhalation and by ingestion.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 3 records

Agency	Metric	Value	ppm	mg/m3	Skin
NIOSH	CEILING	0.2 ppm (1.5 mg/m³)	0.2	1.5	N
ACGIH	CEILING	0.2 ppm [1992]	0.2	-	N
CAL/OSHA	CEILING	0.2 ppm (1.5 mg/m³)	0.2	1.5	N

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

CatalystHardenerChemical reaction regulator

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records

List	Keyword	Source
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 11 of 11 studies

Value	Unit	Endpoint	Route	Species	Source
=2.52	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
W2545087UL	UNII	FDA UNII substance identifier	-	-	openFDA substances
W2545087UL	UNII	FDA UNII substance identifier	-	-	openFDA substances
W2545087UL	UNII	FDA UNII substance identifier	-	-	openFDA substances
W2545087UL	UNII	FDA UNII substance identifier	-	-	openFDA substances
1.7186	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
3.6	mg/L	LC50	Inhalation	-	NTP_ICE_acute_inhalation
=484	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=1017	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=65	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EPA_TSCA_8e
=200	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EPA_TSCA_8e

Showing 11 of 11 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 2 records

Status	Name	EC Number	Link
Registered	Reaction mass of butane-2,2-diyl dihydroperoxide and di-sec-butylhexaoxidane	700-954-4	ECHA overview →
Registered	2-Butanone, peroxide	215-661-2	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1562553

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 2-Butanone peroxide?

2-Butanone peroxide has 11 NOAEL studies in the database. The lowest reported value is 2.52 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 2-Butanone peroxide?

2-Butanone peroxide appears on 2 regulatory/inventory lists including active_ingredient; Europe; Pesticides, Indirect additives food contact (10/2018). Source: EPA CPDat.

What are the occupational exposure limits for 2-Butanone peroxide?

Occupational exposure limits for 2-Butanone peroxide are set by NIOSH, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is 2-Butanone peroxide used in cosmetics?

Yes, 2-Butanone peroxide is also indexed as a cosmetic ingredient under the name MEK Peroxides (Methyl Ethyl Ketone Peroxide / MEKP). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Butanone peroxide come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Butanone peroxide have different safety status in cosmetics vs industrial chemicals?

2-Butanone peroxide is classified GHS Danger (H242, H302, H314, H318, H332, H312, H335, H341) in the chemicals database but is allowed in EU cosmetics.

Is 2-Butanone peroxide used outside industrial chemicals?

2-Butanone peroxide also appears in cosmetics, pharmaceutical databases.