What is the NOAEL for 2-Butanone peroxide?
2-Butanone peroxide has 8 NOAEL studies in the database. The lowest reported value is 2.52 mg/m3 via inhalation in Human. Source: ToxValDB GESTIS DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Butanone peroxide
Also known as: Methyl ethyl ketone peroxide, Chaloxyd MEKP HA 1, EINECS 215-661-2, Esperfoam FR, HI-Point PD-1 (+9 more)
CAS 1338-23-4
2-Butanone peroxide (CAS 1338-23-4) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
View cosmetic safety profile for MEK Peroxides (Methyl Ethyl Ketone Peroxide / MEKP) →
Cross-Vertical Regulatory Divergence
2-Butanone peroxide is classified GHS Danger (H242, H302, H314, H318, H332, H312, H335, H341) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
8
SOURCE
Chemical inventory jurisdictions
Regulatory lists
2
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
19 fields
Name
2-Butanone peroxide
CAS Number
1338-23-4
Molecular Formula
C8H18O6
InChI Key
WFUGQJXVXHBTEM-UHFFFAOYSA-N
Monoisotopic Mass
210.110338
Synonyms
Methyl ethyl ketone peroxideChaloxyd MEKP HA 1EINECS 215-661-2Esperfoam FRHI-Point PD-1Lupersol DELMethylethylketonhydroperoxideNCI-C55447Quickset ExtraQuickset superRCRA waste number U160Sprayset MEKP
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation and by ingestion. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
3 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| NIOSH | CEILING | 0.2 ppm (1.5 mg/m³) | 0.2 | 1.5 | N |
| ACGIH | CEILING | 0.2 ppm [1992] | 0.2 | - | N |
| CAL/OSHA | CEILING | 0.2 ppm (1.5 mg/m³) | 0.2 | 1.5 | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
CatalystHardenerChemical reaction regulator
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =2.52 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| W2545087UL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1.719 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 3.6 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| =484 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =1017 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =65 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB EPA TSCA 8e |
| =200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB EPA TSCA 8e |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA
2 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Reaction mass of butane-2,2-diyl dihydroperoxide and di-sec-butylhexaoxidane | 700-954-4 | ECHA overview → |
| Registered | 2-Butanone, peroxide | 215-661-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL1562553
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include 2-Butanone peroxide?
2-Butanone peroxide appears on 2 regulatory/inventory lists including active_ingredient; Europe; Pesticides, Indirect additives food contact (10/2018). Source: EPA CPDat.
What are the occupational exposure limits for 2-Butanone peroxide?
Occupational exposure limits for 2-Butanone peroxide are set by NIOSH, ACGIH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is 2-Butanone peroxide used in cosmetics?
Yes, 2-Butanone peroxide is also indexed as a cosmetic ingredient under the name MEK Peroxides (Methyl Ethyl Ketone Peroxide / MEKP). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Butanone peroxide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Butanone peroxide have different safety status in cosmetics vs industrial chemicals?
2-Butanone peroxide is classified GHS Danger (H242, H302, H314, H318, H332, H312, H335, H341) in the chemicals database but is allowed in EU cosmetics.
Is 2-Butanone peroxide used outside industrial chemicals?
2-Butanone peroxide also appears in cosmetics, pharmaceutical databases.