What is the NOAEL for Sodium L-ascorbate?
Sodium L-ascorbate has 15 NOAEL studies in the database. The lowest reported value is S033EH8359 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Sodium L-ascorbate
Also known as: (+)-Sodium L-ascorbate (Sodium ascorbate) (l-Ascorbate, sodium), Ascorbic acid sodium derivative, EINECS 205-126-1, Iskia-C, Sodium derivative of 3-oxo-L-gulofuranolactone (+3 more)
CAS 134-03-2
Sodium L-ascorbate (CAS 134-03-2) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
13 fields
Name
Sodium L-ascorbate
CAS Number
134-03-2
DTXSID
DTXSID0020105
Molecular Formula
C6H8O6.Na
InChI Key
PPASLZSBLFJQEF-RXSVEWSESA-M
Synonyms
(+)-Sodium L-ascorbate (Sodium ascorbate) (l-Ascorbate, sodium)Ascorbic acid sodium derivativeEINECS 205-126-1Iskia-CSodium derivative of 3-oxo-L-gulofuranolactoneNatrii ascorbasUNII-S033EH8359Vitamin C, sodium salt
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
46 records
AntioxidantFlavouring and nutrientpH regulating agentFragrancePharmaceuticalProcessing aids not otherwise specifiedChemical reaction regulatorSurface modifierDyeLeavening agentFillerFood preservativeOxidizing agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| S033EH8359 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S033EH8359 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S033EH8359 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S033EH8359 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =5 | % | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =6.84 | % diet | LOEL | oral | Rat | ToxValDB_ECOTOX |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 750 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 1250 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1365 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3420 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 5000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 7500 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
Showing 15 of 15 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Sodium ascorbate | 205-126-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
SODIUM ASCORBATE
ChEMBL Phase
4
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Sodium L-ascorbate?
Sodium L-ascorbate appears on 7 regulatory/inventory lists including IFRA Transparency, inert_ingredient; Pesticides, inert_ingredient; non_food_use; Pesticides, and 4 more. Source: EPA CPDat.
Is Sodium L-ascorbate used in cosmetics?
Yes, Sodium L-ascorbate is also indexed as a cosmetic ingredient under the name Sodium Ascorbate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Sodium L-ascorbate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Sodium L-ascorbate used outside industrial chemicals?
Sodium L-ascorbate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.