Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Sodium Ascorbate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 2500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
Expert Verdict
CAS 134-03-2 (EC 205-126-1). EU: Permitted -- not listed in any restricted Annex of Regulation (EC) 1223/2009; no concentration limits; no dedicated SCCS opinion. US: FDA GRAS for food use (21 CFR); CIR concluded safe as used in cosmetics (2005); re-review initiated September 2024.
Regulatory Flags
Frequently Asked Questions
Is Sodium Ascorbate safe in cosmetics?
CAS 134-03-2 (EC 205-126-1). EU: Permitted -- not listed in any restricted Annex of Regulation (EC) 1223/2009; no concentration limits; no dedicated SCCS opinion. US: FDA GRAS for food use (21 CFR); CIR concluded safe as used in cosmetics (2005); re-review initiated September 2024. The EU classifies Sodium Ascorbate as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Sodium Ascorbate allowed in the EU?
Sodium Ascorbate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Ascorbate do in cosmetics?
Sodium Ascorbate functions as: Antioxidant, collagen booster, skin brightening. It is classified as a Antioxidant in our database. CAS number: 134-03-2.
What is the Margin of Safety for Sodium Ascorbate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Sodium Ascorbate?
The NOAEL (No Observed Adverse Effect Level) for Sodium Ascorbate is 2500 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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