What is the NOAEL for Calcium silicate?
Calcium silicate has 12 NOAEL studies in the database. The lowest reported value is 0.05 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Calcium silicate
Also known as: Silicic acid, calcium salt, EC 215-710-8; 935-756-9, Calcium silicate, synthetic nonfibrous, EINECS 215-710-8, Micro-cel T26 (+4 more)
CAS 1344-95-2
Calcium silicate (CAS 1344-95-2) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
9
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
12 fields
Name
Calcium silicate
CAS Number
1344-95-2
DTXSID
DTXSID4029648
Synonyms
Silicic acid, calcium saltEC 215-710-8; 935-756-9Calcium silicate, synthetic nonfibrousEINECS 215-710-8Micro-cel T26Micro-cel T38Micro-cel T41Promaxon P60UNII-S4255P4G5M
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Hazard Statements | No hazard classification according to GHS criteria |
| Short-term Effects | May cause mechanical irritation to the eyes and respiratory tract. |
| Long-term Effects | Health effects of the substance have been investigated but none have been found |
| Routes of Exposure | Exposure mainly occurs via inhalation. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
3 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 15 mg/m³ (total dust), 5 mg/m³ (respirable fraction) | - | 15 | N |
| NIOSH | TWA | 15 mg/m³ (total dust), 5 mg/m³ (respirable fraction) | - | 15 | N |
| CAL/OSHA | TWA | 10 mg/m³ (total dust), 5 mg/m³ (respirable dust) | - | 10 | N |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
31 records
AbrasiveAbsorbentViscosity modifierOpaciferFillerProcessing aids not otherwise specifiedFlow promoterFlavouring and nutrientAnti-caking agentLubricating agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
9 records
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =4 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =10 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =0.05 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| S4255P4G5M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S4255P4G5M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S4255P4G5M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| S4255P4G5M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =10 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| 1600 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| =1600 | mg/kg bw/day | NOAEL | oral | Hamster | ToxValDB_ECHA_IUCLID |
| ~2500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| ~3200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Silicic acid, calcium salt | 215-710-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
mineral
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
calcium silicate
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E552 — ADI: NOT SPECIFIED mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Calcium silicate?
Calcium silicate appears on 8 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, active_ingredient; animal_products; Europe; pharmaceutical; residue, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 5 more. Source: EPA CPDat.
What are the occupational exposure limits for Calcium silicate?
Occupational exposure limits for Calcium silicate are set by OSHA, NIOSH, CAL/OSHA. 3 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Calcium silicate used in cosmetics?
Yes, Calcium silicate is also indexed as a cosmetic ingredient under the name Calcium Silicate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Calcium silicate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Calcium silicate used outside industrial chemicals?
Calcium silicate also appears in cosmetics, pharmaceutical, food safety databases.