Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Calcium Silicate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1600 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 1600 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1600 mg/kg bw/day | oral | hamster | Developmental | COSMOS_DB |
| NOAEL | 1600 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| dose_tested | 1600 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| dose_tested | 1600 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| dose_tested | 1600 mg/kg bw/day | oral | hamster | Developmental | COSMOS_DB |
| dose_tested | 1600 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
CIR safe (2003/2021 amended). Do not use mined forms in spray/aerosolized products without additional inhalation data. Synthetic forms have less than 0.2% crystalline silica.
Regulatory Flags
Frequently Asked Questions
Is Calcium Silicate safe in cosmetics?
CIR safe (2003/2021 amended). Do not use mined forms in spray/aerosolized products without additional inhalation data. Synthetic forms have less than 0.2% crystalline silica. The EU classifies Calcium Silicate as "permitted". Safety rating: GOOD. 8 toxicological study endpoint(s) are available in our database.
Is Calcium Silicate allowed in the EU?
Calcium Silicate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Silicate do in cosmetics?
Calcium Silicate functions as: Absorbent, Bulking Agent, Opacifying, Pearlescent, Viscosity Controlling. It is classified as a cosmetic ingredient in our database. CAS number: 1344-95-2.
What is the Margin of Safety for Calcium Silicate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Calcium Silicate?
The NOAEL (No Observed Adverse Effect Level) for Calcium Silicate is 1600 mg/kg bw/day based on a Developmental study via oral route in mouse. A total of 8 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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