Is Calcium Silicate safe in cosmetics?
Calcium Silicate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Calcium Silicate
Also known as: Silicic acid, calcium salt, EC 215-710-8; 935-756-9, Calcium silicate, synthetic nonfibrous, EINECS 215-710-8, Micro-cel T26 (+4 more)
INCI: CALCIUM SILICATE
Calcium Silicate (CAS 1344-95-2) is a cosmetic cosmetic ingredient functioning as Absorbent, Bulking Agent, Opacifying, Pearlescent, Viscosity Controlling. NOAEL 1600 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1344-95-2 →
Auto-generated CPSR Part A draft with source citations
Function
Absorbent, Bulking Agent, Opacifying, Pearlescent, Viscosity Controlling
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
calcium bis(trihydroxy(oxido)silane)
InChIKey
LECAAGVQUHQAJK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
OTC skin protectant. GRAS per JECFA. CIR concluded safe (2003, amended 2021) except insufficient data for naturally-sourced forms in inhaled products.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Calcium Silicate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Calcium Silicate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1600 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | =1600 mg/kg bw/day | oral | Hamster | developmental | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Hazard Statements
No hazard classification according to GHS criteria
Short-term Exposure Effects
May cause mechanical irritation to the eyes and respiratory tract.
Long-term Exposure Effects
Health effects of the substance have been investigated but none have been found
Routes of Exposure
Exposure mainly occurs via inhalation.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Calcium Silicate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
deodorant
{"cas_number": "1344-95-2", "ingredient_class": "sweat_absorber", "mechanism_of_action": "odor_absorption", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "8-12", "odor_reduction_pct": "30-50", "bacteriostatic": "no", "bactericidal": "no", "microbiome_impact": "neutral", "axillary_microbiome_effect": "varies by ingredient", "MIC_value_if_antimicrobial": "varies", "…
mineral_clay
{"cas_number": "1344-95-2", "ingredient_class": "calcium_compound", "chemical_formula": "CaSiO3", "mineral_origin": "synthetic", "particle_size_range_um": "1-20", "surface_area_m2_per_g": "10-50", "crystal_structure": "triclinic", "color_appearance": "white", "opacity": "opaque", "refractive_index": "1.54", "oil_absorption_g_per_100g": "80-180", "water_absorption_capacity": "150-300%", "surface_ch…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Evidence for Carcinogenicity
A4; Not classifiable as a human carcinogen. /Calcium silicate (synthetic nonfibrous)/ | There is inadequate evidence in humans for the carcinogenicity of wollastonite. There is inadequate evidence in experimental animals for the carcinogenicity of wollastonite. Overall evaluation: Wollastonite cannot be classifed as to its carcinogenicity to humans (Group 3).
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
1401
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
May cause mechanical irritation to the eyes and the respiratory tract.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Evaluation
CALCIUM SILICATE | 2015 | NOT SPECIFIED | An ADI 'not specified' for silicon dioxide and certain silicates including calcium silicate was established at the 29th JECFA (1985) | TRS 995-JECFA 80/38 | FAS 5/NMRS 53A-JECFA 17/21 (1973)
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Abrasive
Absorbent
Anti-caking agent
Filler
Flavouring and nutrient
Flow promoter
Lubricating agent
Opacifer
Processing aids not otherwise specified
Viscosity modifier
Regulatory List Membership (2)
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Calcium Silicate.
Regulatory Flags
epa_safer_alternative
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Calcium Silicate by CAS number or substance name.
Studies
2
Lowest NOAEL
1600 mg/kg bw/day
Highest NOAEL
1600 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Known Synonyms
Silicic acid, calcium salt
EC 215-710-8; 935-756-9
Calcium silicate, synthetic nonfibrous
EINECS 215-710-8
Micro-cel T26
Micro-cel T38
Micro-cel T41
Promaxon P60
UNII-S4255P4G5M
Chemical Function
Abrasive
Absorbent
Viscosity modifier
Opacifer
Filler
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
active_ingredient; animal_products; Europe; pharmaceutical; residue
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Canada; pharmaceutical
Canada; consumer_product; Substances in Products - Canada (4/2014)
inert_ingredient; Pesticides
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
calcium silicate
ChEMBL ID
CHEMBL2108942
Frequently Asked Questions
Is Calcium Silicate allowed in the EU?
Calcium Silicate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Silicate do in cosmetics?
Calcium Silicate functions as: Absorbent, Bulking Agent, Opacifying, Pearlescent, Viscosity Controlling. It is classified as a cosmetic ingredient in our database. CAS number: 1344-95-2.
What is the NOAEL for Calcium Silicate?
The NOAEL (No Observed Adverse Effect Level) for Calcium Silicate is 1600 mg/kg bw/day based on a Developmental study via oral route in mouse. A total of 2 study endpoints are available. Source: COSMOS_DB.
Is Calcium Silicate used outside cosmetics?
Calcium Silicate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Calcium Silicate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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