NOAEL Data REACH Registered Cosmetic Ingredient

2-Isobutyl-4-methyltetrahydro-2H-pyran

Also known as: 2H-Pyran, tetrahydro-4-methyl-2-(2-methylpropyl)-, 2-Isobutyl-4-methyl-tetrahydro-pyran, Dihydrorose oxide, Pyran, tetrahydro-2-isobutyl-4-methyl-, Tetrahydro-4-methyl-2-(2-methylpropyl)-2H-pyran (+6 more)

CAS 13477-62-8

2-Isobutyl-4-methyltetrahydro-2H-pyran (CAS 13477-62-8) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Tetrahydro-2-isobutyl-4-methyl-2H-pyran →

SOURCE noael studies public
NOAEL studies
4
SOURCE chemical inventory jurisdictions
Regulatory lists
1
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields
Name
2-Isobutyl-4-methyltetrahydro-2H-pyran
CAS Number
13477-62-8
DTXSID
DTXSID50864412
Molecular Formula
C10H20O
InChI Key
LETLQGKRPMMKKC-UHFFFAOYSA-N
Monoisotopic Mass
156.151415
Synonyms
2H-Pyran, tetrahydro-4-methyl-2-(2-methylpropyl)-2-Isobutyl-4-methyl-tetrahydro-pyranDihydrorose oxidePyran, tetrahydro-2-isobutyl-4-methyl-Tetrahydro-4-methyl-2-(2-methylpropyl)-2H-pyranEC No.: 236-770-1EINECS 236-770-1Tetrahydro-2-isobutyl-4-methyl-2H-pyran2-(2′-Methylpropyl)-4-methyltetrahydropyran236-770-1Rose dihydrooxide

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Fragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records
ListKeywordSource
IFRA TransparencyIFRAIFRA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 4 of 4 studies
ValueUnitEndpointRouteSpeciesSource
=14.69mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
=23100mg/m3LELinhalationRatToxValDB_ECHA_IUCLID
=500mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=1000mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID

Showing 4 of 4 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
RegisteredTetrahydro-2-isobutyl-4-methyl-2H-pyran236-770-1ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for 2-Isobutyl-4-methyltetrahydro-2H-pyran?

2-Isobutyl-4-methyltetrahydro-2H-pyran has 4 NOAEL studies in the database. The lowest reported value is 14.69 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include 2-Isobutyl-4-methyltetrahydro-2H-pyran?

2-Isobutyl-4-methyltetrahydro-2H-pyran appears on 1 regulatory/inventory list including IFRA Transparency. Source: EPA CPDat.

Is 2-Isobutyl-4-methyltetrahydro-2H-pyran used in cosmetics?

Yes, 2-Isobutyl-4-methyltetrahydro-2H-pyran is also indexed as a cosmetic ingredient under the name Tetrahydro-2-isobutyl-4-methyl-2H-pyran. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Isobutyl-4-methyltetrahydro-2H-pyran come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 2-Isobutyl-4-methyltetrahydro-2H-pyran used outside industrial chemicals?

2-Isobutyl-4-methyltetrahydro-2H-pyran also appears in cosmetics databases.