Also known as: 2H-Pyran, tetrahydro-4-methyl-2-(2-methylpropyl)-, 2-Isobutyl-4-methyl-tetrahydro-pyran, Dihydrorose oxide, Pyran, tetrahydro-2-isobutyl-4-methyl-, Tetrahydro-4-methyl-2-(2-methylpropyl)-2H-pyran (+5 more)
INCI: TETRAHYDRO-2-ISOBUTYL-4-METHYL-2H-PYRAN (FRAGRANCE INGREDIENT)
Tetrahydro-2-isobutyl-4-methyl-2H-pyran (CAS 13477-62-8) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. NOAEL 500 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 13477-62-8 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrahydro-2-isobutyl-4-methyl-2H-pyran.
Calculate MoS for your specific formulation with the MoS Calculator.
2 study endpoints found for Tetrahydro-2-isobutyl-4-methyl-2H-pyran. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =500 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-calculated NOAEL → SED → MoS audit trail for Tetrahydro-2-isobutyl-4-methyl-2H-pyran across SCCS product categories, with measured dermal absorption where available.
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Expert safety assessment and concern-level summary for Tetrahydro-2-isobutyl-4-methyl-2H-pyran.
Public NOAEL study rows linked to Tetrahydro-2-isobutyl-4-methyl-2H-pyran by CAS number or substance name.
Tetrahydro-2-isobutyl-4-methyl-2H-pyran has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Tetrahydro-2-isobutyl-4-methyl-2H-pyran EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Tetrahydro-2-isobutyl-4-methyl-2H-pyran functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 13477-62-8.
The NOAEL (No Observed Adverse Effect Level) for Tetrahydro-2-isobutyl-4-methyl-2H-pyran is =500 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Tetrahydro-2-isobutyl-4-methyl-2H-pyran also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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