Tetrahydro-2-isobutyl-4-methyl-2H-pyran
INCI: TETRAHYDRO-2-ISOBUTYL-4-METHYL-2H-PYRAN (FRAGRANCE INGREDIENT)
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Tetrahydro-2-isobutyl-4-methyl-2H-pyran. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Not genotoxic; no reproductive, sensitization, or photoirritation concerns per RIFM; Cramer Class III classification requires TTC-based assessment
Regulatory Flags
Frequently Asked Questions
Is Tetrahydro-2-isobutyl-4-methyl-2H-pyran safe in cosmetics?
Not genotoxic; no reproductive, sensitization, or photoirritation concerns per RIFM; Cramer Class III classification requires TTC-based assessment The EU classifies Tetrahydro-2-isobutyl-4-methyl-2H-pyran as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.
Is Tetrahydro-2-isobutyl-4-methyl-2H-pyran allowed in the EU?
Tetrahydro-2-isobutyl-4-methyl-2H-pyran EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrahydro-2-isobutyl-4-methyl-2H-pyran do in cosmetics?
Tetrahydro-2-isobutyl-4-methyl-2H-pyran functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 13477-62-8.
What is the Margin of Safety for Tetrahydro-2-isobutyl-4-methyl-2H-pyran?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Tetrahydro-2-isobutyl-4-methyl-2H-pyran?
The NOAEL (No Observed Adverse Effect Level) for Tetrahydro-2-isobutyl-4-methyl-2H-pyran is 500 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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