Also known as: 2-Naphthol, 2-naftol, Caswell No. 590, Developer sodium, EINECS 205-182-7 (+14 more)
CAS 135-19-3
2-Naphthalenol (CAS 135-19-3) is a chemical substance with GHS signal word Warning; key hazard signal: H332; H302; H400. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
View cosmetic safety profile for 2-Naphthol (β-Naphthol) 🔴 →
2-Naphthalenol is prohibited in EU cosmetics but has active industrial GHS classifications (H332, H302, H400).
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Acute Tox. 4 *; Aquatic Acute 1 | H332; H302; H400 | GHS07; GHS09 | Warning |
International Chemical Safety Card hazard and exposure summary.
| Field | Value |
|---|---|
| Short-term Effects | The substance is severely irritating to the eyes. |
| Long-term Effects | Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the kidneys, blood and eyes. This may result in kidney impairment, anaemia and lens opacities. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| banned; Europe; Personal care | European Commission | CosIng |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 46.014553587878 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 22.4415221419953 | uM | ACC | - | - | NTP_ICE_endocrine |
| 119 | uL/min/10^6 cells | Clint | - | Rat | NTP_ICE_adme_parameters |
| =1.76 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| P2Z71CIK5H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P2Z71CIK5H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P2Z71CIK5H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P2Z71CIK5H | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6.98e-7 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| 0.0513 | fraction | Fu | - | Rat | NTP_ICE_adme_parameters |
| >0.77 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =1960 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.0874 | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 14 of 14 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-naphthol | 205-182-7 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
Same-CAS cosmetic ingredient record for cross-vertical context.
Same-CAS pharmaceutical records from drug and bioactivity sources.
2-Naphthalenol (CAS 135-19-3) is classified under EU CLP Annex VI as Acute Tox. 4 *; Acute Tox. 4 *; Aquatic Acute 1 with signal word Warning. Hazard statements: H332; H302; H400. Source: EU CLP Annex VI (ECHA).
2-Naphthalenol has 14 NOAEL studies in the database. The lowest reported value is 1.76 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
2-Naphthalenol appears on 4 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe, Indirect additives food contact (10/2018), and 1 more. Source: EPA CPDat.
Yes, 2-Naphthalenol is also indexed as a cosmetic ingredient under the name 2-Naphthol (β-Naphthol) 🔴. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
2-Naphthalenol is prohibited in EU cosmetics but has active industrial GHS classifications (H332, H302, H400).
2-Naphthalenol also appears in cosmetics, pharmaceutical databases.