What is the NOAEL for Disodium 2-hydroxyethyliminodi(acetate)?
Disodium 2-hydroxyethyliminodi(acetate) has 7 NOAEL studies in the database. The lowest reported value is 2.9 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Disodium 2-hydroxyethyliminodi(acetate)
Also known as: Glycine, N-(carboxymethyl)-N-(2-hydroxyethyl)-, sodium salt (1:2), Ethanoldiglycine disodium salt, Caswell No. 404, Disodium N-(2-hydroxyethyl)iminodiacetate, EINECS 205-187-4 (+3 more)
CAS 135-37-5
Disodium 2-hydroxyethyliminodi(acetate) (CAS 135-37-5) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Disodium Hydroxyethyliminodiacetate →
Cross-Vertical Regulatory Divergence
Disodium 2-hydroxyethyliminodi(acetate) is classified GHS CMR hazard (H302, H315, H319, H351) in the chemicals database but is restricted in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Disodium 2-hydroxyethyliminodi(acetate)
CAS Number
135-37-5
DTXSID
DTXSID8042008
Molecular Formula
C6H11NO5.2Na
InChI Key
ZTVCAEHRNBOTLI-UHFFFAOYSA-L
Monoisotopic Mass
223.043261
Synonyms
Glycine, N-(carboxymethyl)-N-(2-hydroxyethyl)-, sodium salt (1:2)Ethanoldiglycine disodium saltCaswell No. 404Disodium N-(2-hydroxyethyl)iminodiacetateEINECS 205-187-4EPA Pesticide Chemical Code 039102UNII-Q796430V9NGlycine, N-(carboxymethyl)-N-(2-hydroxyethyl)-, disodium salt
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Chelating agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =2.9 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| Q796430V9N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q796430V9N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q796430V9N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q796430V9N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =41 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Disodium 2-hydroxyethyliminodi(acetate) | 205-187-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Cosmetic Ingredient
Frequently Asked Questions
What regulatory lists include Disodium 2-hydroxyethyliminodi(acetate)?
Disodium 2-hydroxyethyliminodi(acetate) appears on 1 regulatory/inventory list including inert_ingredient; non_food_use; Pesticides. Source: EPA CPDat.
Is Disodium 2-hydroxyethyliminodi(acetate) used in cosmetics?
Yes, Disodium 2-hydroxyethyliminodi(acetate) is also indexed as a cosmetic ingredient under the name Disodium Hydroxyethyliminodiacetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Disodium 2-hydroxyethyliminodi(acetate) come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does Disodium 2-hydroxyethyliminodi(acetate) have different safety status in cosmetics vs industrial chemicals?
Disodium 2-hydroxyethyliminodi(acetate) is classified GHS CMR hazard (H302, H315, H319, H351) in the chemicals database but is restricted in EU cosmetics.
Is Disodium 2-hydroxyethyliminodi(acetate) used outside industrial chemicals?
Disodium 2-hydroxyethyliminodi(acetate) also appears in cosmetics databases.