Disodium Hydroxyethyliminodiacetate

INCI: DISODIUM HYDROXYETHYLIMINODIACETATE

CAS Number
135-37-5
Function
Chelating agent (HEIDA salt — structural analog of EDTA)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Permitted — FDA UNII Q796430V9N; also EPA-registered pesticide ingredient (Caswell No. 404)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

ECHA C&L inventory shows Carc. 2 classification from 43.3% of notifiers; H302 (harmful if swallowed), H315 (skin irritation), H319 (eye irritation). Requires thorough risk assessment in CPSR — read-across from EDTA safety data insufficient without Carc. 2 resolution.

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Concern Level: High

Frequently Asked Questions

Is Disodium Hydroxyethyliminodiacetate safe in cosmetics?

ECHA C&L inventory shows Carc. 2 classification from 43.3% of notifiers; H302 (harmful if swallowed), H315 (skin irritation), H319 (eye irritation). Requires thorough risk assessment in CPSR — read-across from EDTA safety data insufficient without Carc. 2 resolution. The EU classifies Disodium Hydroxyethyliminodiacetate as "restricted". Safety rating: POOR.

Is Disodium Hydroxyethyliminodiacetate allowed in the EU?

Disodium Hydroxyethyliminodiacetate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Disodium Hydroxyethyliminodiacetate do in cosmetics?

Disodium Hydroxyethyliminodiacetate functions as: Chelating agent (HEIDA salt — structural analog of EDTA). It is classified as a cosmetic ingredient in our database. CAS number: 135-37-5.

What is the Margin of Safety for Disodium Hydroxyethyliminodiacetate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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