Is Disodium Hydroxyethyliminodiacetate safe in cosmetics?
Disodium Hydroxyethyliminodiacetate has a safety rating of "POOR" in our database. EU status: restricted. US status: permitted.
Poor
Cosmetic Ingredient
Disodium Hydroxyethyliminodiacetate
Also known as: Disodium 2-hydroxyethyliminodi(acetate), Glycine, N-(carboxymethyl)-N-(2-hydroxyethyl)-, sodium salt (1:2), Ethanoldiglycine disodium salt, Caswell No. 404, Disodium N-(2-hydroxyethyl)iminodiacetate (+4 more)
INCI: DISODIUM HYDROXYETHYLIMINODIACETATE
Disodium Hydroxyethyliminodiacetate (CAS 135-37-5) is a cosmetic cosmetic ingredient functioning as Chelating agent (HEIDA salt — structural analog of EDTA). EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 135-37-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Disodium Hydroxyethyliminodiacetate is classified GHS CMR hazard (H302, H315, H319, H351) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Chelating agent (HEIDA salt — structural analog of EDTA)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
disodium;2-[carboxylatomethyl(2-hydroxyethyl)amino]acetate
InChIKey
ZTVCAEHRNBOTLI-UHFFFAOYSA-L
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted — FDA UNII Q796430V9N; also EPA-registered pesticide ingredient (Caswell No. 404)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Disodium Hydroxyethyliminodiacetate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Expert Verdict
Expert safety assessment and concern-level summary for Disodium Hydroxyethyliminodiacetate.
Known Synonyms
Disodium 2-hydroxyethyliminodi(acetate)
Glycine, N-(carboxymethyl)-N-(2-hydroxyethyl)-, sodium salt (1:2)
Ethanoldiglycine disodium salt
Caswell No. 404
Disodium N-(2-hydroxyethyl)iminodiacetate
EINECS 205-187-4
EPA Pesticide Chemical Code 039102
UNII-Q796430V9N
Glycine, N-(carboxymethyl)-N-(2-hydroxyethyl)-, disodium salt
Chemical Function
Chelating agent
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Disodium Hydroxyethyliminodiacetate allowed in the EU?
Disodium Hydroxyethyliminodiacetate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Disodium Hydroxyethyliminodiacetate do in cosmetics?
Disodium Hydroxyethyliminodiacetate functions as: Chelating agent (HEIDA salt — structural analog of EDTA). It is classified as a cosmetic ingredient in our database. CAS number: 135-37-5.
Is Disodium Hydroxyethyliminodiacetate used outside cosmetics?
Disodium Hydroxyethyliminodiacetate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Disodium Hydroxyethyliminodiacetate have different safety status in cosmetics vs industrial chemicals?
Disodium Hydroxyethyliminodiacetate is classified GHS CMR hazard (H302, H315, H319, H351) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Disodium Hydroxyethyliminodiacetate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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