What is the NOAEL for E-Cinnamic acid?
E-Cinnamic acid has 9 NOAEL studies in the database. The lowest reported value is 14.93932984748 uM. Source: NTP_ICE_endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
E-Cinnamic acid
Also known as: trans-Cinnamic acid, (2E)-3-Phenyl-2-propeonic acid, 4-09-00-02002, BRN 1905952, EINECS 205-398-1 (+15 more)
CAS 140-10-3
E-Cinnamic acid (CAS 140-10-3) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
E-Cinnamic acid
CAS Number
140-10-3
DTXSID
DTXSID5022489
Molecular Formula
C9H8O2
InChI Key
WBYWAXJHAXSJNI-VOTSOKGWSA-N
Monoisotopic Mass
148.052429
Synonyms
trans-Cinnamic acid(2E)-3-Phenyl-2-propeonic acid4-09-00-02002BRN 1905952EINECS 205-398-1(2E)-2-Phenyl-2-propenoate(2E)-3-Phenyl-2-propenoate(E)-3-Phenylacrylate(E)-3-Phenylprop-2-enoate(E)-3-phenyl-2-propenoic acid(E)-CinnamateBenzeneacrylic acid
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 25.8317108495128 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 14.93932984748 | uM | ACC | - | - | NTP_ICE_endocrine |
| U14A832J8D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U14A832J8D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U14A832J8D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U14A832J8D | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.0499 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.101 | unitless | Model Score | - | - | NTP_ICE_endocrine |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | trans-cinnamic acid | 205-398-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CINNAMIC ACID
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
8
Frequently Asked Questions
What regulatory lists include E-Cinnamic acid?
E-Cinnamic acid appears on 4 regulatory/inventory lists including detected; Europe; Personal care - sexual wellness, Europe; Personal care - sexual wellness, IFRA Transparency, and 1 more. Source: EPA CPDat.
Is E-Cinnamic acid used in cosmetics?
Yes, E-Cinnamic acid is also indexed as a cosmetic ingredient under the name Cinnamic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for E-Cinnamic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is E-Cinnamic acid used outside industrial chemicals?
E-Cinnamic acid also appears in cosmetics, pharmaceutical databases.