Is Cinnamic Acid safe in cosmetics?
Cinnamic Acid has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Cinnamic Acid
Also known as: trans-Cinnamic acid, (2E)-3-Phenyl-2-propeonic acid, 4-09-00-02002, BRN 1905952, EINECS 205-398-1 (+14 more)
INCI: CINNAMIC ACID
Cinnamic Acid (CAS 140-10-3) is a cosmetic fragrance functioning as Perfuming, Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 140-10-3 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming, Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(E)-3-phenylprop-2-enoic acid
InChIKey
WBYWAXJHAXSJNI-VOTSOKGWSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FEMA GRAS as flavoring. Permitted under RIFM/IFRA framework
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cinnamic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Cinnamic Acid based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.2%
Cross-reactivity Group
balsam-of-peru-group
Reaction Type
contact-dermatitis
IFRA Restricted
Source: EU 2023/1545; SCCS/1459/11
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (1 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_in_vitro | 17.8 | In vitro; excised human skin; flow-through diffusion cells | Human excised skin (non-occluded) | Bronaugh et al. 1985 (1985) |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "yes", "allergen_class": "fragrance", "cross_reactivity_group": "balsam-of-peru-group", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "yes", "source": "EU 2023/1545; SCCS/1459/11"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Regulatory (4)
JECFA Number
657
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-PHENYLACRYLIC ACID | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/22 | FAS 46-JECFA 55/79
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
beta-PHENYLACRYLIC ACID | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/22 | FAS 46-JECFA 55/79
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
CINNAMIC ACID | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/22 | FAS 46-JECFA 55/79
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Cinnamic Acid.
Regulatory Flags
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Cinnamic Acid by CAS number or substance name.
Studies
1
Lowest NOAEL
53.4 mg/kg bw/day
Highest NOAEL
53.4 mg/kg bw/day
COSMOS_DB
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 17.8 | In vitro; excised human skin; flow-through diffusion cells | 6% Oleth-20 receptor fluid |
Known Synonyms
trans-Cinnamic acid
(2E)-3-Phenyl-2-propeonic acid
4-09-00-02002
BRN 1905952
EINECS 205-398-1
(2E)-2-Phenyl-2-propenoate
(2E)-3-Phenyl-2-propenoate
(E)-3-Phenylacrylate
(E)-3-Phenylprop-2-enoate
(E)-3-phenyl-2-propenoic acid
(E)-Cinnamate
Benzeneacrylic acid
Phenylacrylic acid
trans-3-Phenyl-2-propenoate
trans-3-Phenyl-2-propenoic acid
trans-3-Phenylacrylate
trans-Cinnamate
trans-Zimtsaeure
trans-b-Carboxystyrene
Chemical Function
Fragrance
Regulatory Lists
detected; Europe; Personal care - sexual wellness
detected; Europe; Personal care - sexual wellness
Europe; Personal care - sexual wellness
IFRA Transparency
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CINNAMIC ACID
ChEMBL ID
CHEMBL27246
Frequently Asked Questions
Is Cinnamic Acid allowed in the EU?
Cinnamic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cinnamic Acid do in cosmetics?
Cinnamic Acid functions as: Perfuming, Skin Conditioning. It is classified as a Fragrance in our database. CAS number: 140-10-3.
Is Cinnamic Acid used outside cosmetics?
Cinnamic Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cinnamic Acid compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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