What is the NOAEL for Phenethyl isovalerate?
Phenethyl isovalerate has 10 NOAEL studies in the database. The lowest reported value is 39.5 % via Dermal in Mouse. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Phenethyl isovalerate
Also known as: Butanoic acid, 3-methyl-, 2-phenylethyl ester, 4-06-00-03074, Benzylcarbinyl isopentanoate, Benzylcarbinyl isovalerate, Benzylcarbinyl 3-methylbutanoate (+14 more)
CAS 140-26-1
Phenethyl isovalerate (CAS 140-26-1) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
25 fields
Name
Phenethyl isovalerate
CAS Number
140-26-1
DTXSID
DTXSID2059693
Molecular Formula
C13H18O2
InChI Key
JIMGVOCOYZFDKB-UHFFFAOYSA-N
Monoisotopic Mass
206.13068
Synonyms
Butanoic acid, 3-methyl-, 2-phenylethyl ester4-06-00-03074Benzylcarbinyl isopentanoateBenzylcarbinyl isovalerateBenzylcarbinyl 3-methylbutanoateBRN 2504902EINECS 205-406-3FEMA No. 2871NSC 21899Phenethyl isovalerianatePhenethyl 3-methylbutyratePhenylethyl isovalerate
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
10 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 39.5 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| K86JE60K0L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K86JE60K0L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K86JE60K0L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K86JE60K0L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1296 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =6220 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =300 | mg/kg bw/day | LEL | oral | Chicken | ToxValDB_EFSA |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Phenethyl isovalerate | 205-406-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Phenethyl isovalerate?
Phenethyl isovalerate appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Phenethyl isovalerate used in cosmetics?
Yes, Phenethyl isovalerate is also indexed as a cosmetic ingredient under the name Phenethyl Isovalerate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Phenethyl isovalerate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Phenethyl isovalerate used outside industrial chemicals?
Phenethyl isovalerate also appears in cosmetics, food safety, cannabis databases.