Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Phenethyl Isovalerate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | mouse | oral | REACH |
| NOEL | 25 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 870 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Negative in BlueScreen genotoxicity assay; not PBT; PEC/PNEC < 1 for EU and NA
Regulatory Flags
Frequently Asked Questions
Is Phenethyl Isovalerate safe in cosmetics?
Negative in BlueScreen genotoxicity assay; not PBT; PEC/PNEC < 1 for EU and NA The EU classifies Phenethyl Isovalerate as "permitted". Safety rating: GOOD. 5 toxicological study endpoint(s) are available in our database.
Is Phenethyl Isovalerate allowed in the EU?
Phenethyl Isovalerate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenethyl Isovalerate do in cosmetics?
Phenethyl Isovalerate functions as: Fragrance (perfuming agent); floral/fruity odor profile. It is classified as a cosmetic ingredient in our database. CAS number: 140-26-1.
What is the Margin of Safety for Phenethyl Isovalerate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Phenethyl Isovalerate?
The NOAEL (No Observed Adverse Effect Level) for Phenethyl Isovalerate is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 5 study endpoints are available. Source: REACH.
Compliance Tools
Check Phenethyl Isovalerate compliance across multiple jurisdictions:
Related Ingredients
Is Phenethyl Isovalerate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Phenethyl Isovalerate in your formulation.