What is the NOAEL for 4-Tolyl acetate?
4-Tolyl acetate has 13 NOAEL studies in the database. The lowest reported value is 4 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-Tolyl acetate
Also known as: Acetic acid, 4-methylphenyl ester, 4-06-00-02112, p-Acetoxytoluene, 4-Acetoxytoluene, BRN 1908125 (+15 more)
CAS 140-39-6
4-Tolyl acetate (CAS 140-39-6) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
4-Tolyl acetate
CAS Number
140-39-6
DTXSID
DTXSID0046567
Molecular Formula
C9H10O2
InChI Key
CDJJKTLOZJAGIZ-UHFFFAOYSA-N
Monoisotopic Mass
150.06808
Synonyms
Acetic acid, 4-methylphenyl ester4-06-00-02112p-Acetoxytoluene4-AcetoxytolueneBRN 1908125p-Cresol acetateCresyl acetateCresylic acetate, p-EINECS 205-413-1FEMA No. 3073p-Methylphenyl acetate4-Methylphenyl acetate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 4.8 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 4 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| =39.8 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 42I5PWW20C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 42I5PWW20C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 42I5PWW20C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 42I5PWW20C | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 4.167 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 2760 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 3312 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | p-tolyl acetate | 205-413-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL501246
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 4-Tolyl acetate?
4-Tolyl acetate appears on 5 regulatory/inventory lists including active_ingredient; Europe; Pesticides, IFRA Transparency, Europe, and 2 more. Source: EPA CPDat.
Is 4-Tolyl acetate used in cosmetics?
Yes, 4-Tolyl acetate is also indexed as a cosmetic ingredient under the name CRESYL ACETATE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-Tolyl acetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 4-Tolyl acetate used outside industrial chemicals?
4-Tolyl acetate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.