Is CRESYL ACETATE safe in cosmetics?
CRESYL ACETATE has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
CRESYL ACETATE
Also known as: Acetic acid, 4-methylphenyl ester, 4-06-00-02112, p-Acetoxytoluene, 4-Acetoxytoluene, BRN 1908125 (+14 more)
CRESYL ACETATE (CAS 140-39-6) is a cosmetic cosmetic ingredient functioning as Perfuming. NOAEL 610.66 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 140-39-6 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
(4-methylphenyl) acetate
InChIKey
CDJJKTLOZJAGIZ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for CRESYL ACETATE across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
| HMT | - | 0 | 2760 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
699
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
p-CRESYL ACETATE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
p-TOLYL ACETATE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for CRESYL ACETATE.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
fda_food_additive
Known Synonyms
Acetic acid, 4-methylphenyl ester
4-06-00-02112
p-Acetoxytoluene
4-Acetoxytoluene
BRN 1908125
p-Cresol acetate
Cresylic acetate, p-
EINECS 205-413-1
FEMA No. 3073
p-Methylphenyl acetate
4-Methylphenyl acetate
Narceol
NSC 43244
Paracresyl acetate
p-Tolyl ethanoate
UNII-42I5PWW20C
Tolylacetate
p-Cresyl acetate
p-Tolyacetate
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
active_ingredient; Europe; Pesticides
active_ingredient; Europe; Pesticides
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL501246
Frequently Asked Questions
Is CRESYL ACETATE allowed in the EU?
CRESYL ACETATE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CRESYL ACETATE do in cosmetics?
CRESYL ACETATE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 140-39-6.
Is CRESYL ACETATE used outside cosmetics?
CRESYL ACETATE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CRESYL ACETATE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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