What is the NOAEL for Tocopherols?
Tocopherols has 17 NOAEL studies in the database. The lowest reported value is 43.8 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Tocopherols
Also known as: dl-Tocopherol mixture, natural (alpha, beta, gamma and delta), Tocopherol, Tocoferoles, Golden Tocopherol 70, Tocopherol (Vitamin E) (+15 more)
CAS 1406-66-2
Tocopherols (CAS 1406-66-2) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
17
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Tocopherols
CAS Number
1406-66-2
DTXSID
DTXSID8021357
Synonyms
dl-Tocopherol mixture, natural (alpha, beta, gamma and delta)TocopherolTocoferolesGolden Tocopherol 70Tocopherol (Vitamin E)MethyltocolsUNII-R0ZB2556P8Irganox E 217DFGrindox 497E-Oil 805DCovi-Ox T 90EU-CCopherol F 1300
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
AntioxidantPharmaceuticalDeodorizerSoftener and conditionerFragranceHumectantOtherBinderProcessing aids not otherwise specified
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 17 of 17 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =43.8 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| R0ZB2556P8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R0ZB2556P8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R0ZB2556P8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R0ZB2556P8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >15000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 13 | mg/kg bw/day | NOAEL | oral | guinea pig | COSMOS_DB |
| 40 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 66 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 521 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 533 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 544 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 550 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 618 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 750 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =400 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 17 of 17 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Tocopherols | 604-195-9 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
5.4%
Category
surfactant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ChEMBL Phase
Not listed
Adverse Events
967
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include Tocopherols?
Tocopherols appears on 4 regulatory/inventory lists including Europe; Personal care, Canada; pharmaceutical, animal_products, and 1 more. Source: EPA CPDat.
Is Tocopherols used in cosmetics?
Yes, Tocopherols is also indexed as a cosmetic ingredient under the name Tocopherol (Vitamin E). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Tocopherols come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Tocopherols used outside industrial chemicals?
Tocopherols also appears in cosmetics, pharmaceutical, food safety databases.