Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Tocopherol (Vitamin E). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 13 mg/kg bw/day | oral | guinea pig | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 750 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | hamster | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 750 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 66 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 40 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Good safety profile with antioxidant efficacy; restricted in EU with concentration limits, permitted in US.
Regulatory Flags
Frequently Asked Questions
Is Tocopherol (Vitamin E) safe in cosmetics?
Good safety profile with antioxidant efficacy; restricted in EU with concentration limits, permitted in US. The EU classifies Tocopherol (Vitamin E) as "restricted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Tocopherol (Vitamin E) allowed in the EU?
Tocopherol (Vitamin E) EU regulatory status: restricted. Maximum allowed concentration: 5.4%. This is based on EU Regulation 1223/2009 and its amendments.
What does Tocopherol (Vitamin E) do in cosmetics?
Tocopherol (Vitamin E) functions as: Antioxidant. It is classified as a Surfactant in our database. CAS number: 1406-66-2.
What is the Margin of Safety for Tocopherol (Vitamin E)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Tocopherol (Vitamin E)?
The NOAEL (No Observed Adverse Effect Level) for Tocopherol (Vitamin E) is 1000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Tocopherol (Vitamin E) compliance across multiple jurisdictions:
Related Ingredients
Is Tocopherol (Vitamin E) in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Tocopherol (Vitamin E) in your formulation.