Is Tocopherol (Vitamin E) safe in cosmetics?
Tocopherol (Vitamin E) has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Good
Surfactant
Tocopherol (Vitamin E)
Also known as: dl-Tocopherol mixture, natural (alpha, beta, gamma and delta), Tocoferoles, Golden Tocopherol 70, Methyltocols, UNII-R0ZB2556P8 (+13 more)
INCI: TOCOPHEROL
Tocopherol (Vitamin E) (CAS 1406-66-2) is a cosmetic surfactant functioning as Antioxidant. NOAEL 400 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 5.4%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 1406-66-2 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant
Safety Rating
GOOD
Regulatory Status
EU EU Status
restricted
EU Max Conc.
5.4%
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tocopherol (Vitamin E).
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Tocopherol (Vitamin E) across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Face Cream | 0.1–1 | 2 | CIR/VCRP |
| Body Lotion | 0.1–1 | 2 | CIR/VCRP |
| Sunscreen | 0.1–0.5 | 1 | CIR/VCRP |
Additional Ingredient Properties
6 property records from structured ingredient metadata.
baby_pediatric
{"cas_number": "59-02-9/10191-41-0", "ingredient_class": "preservative_baby_safe", "pediatric_safety_rating": "excellent", "minimum_age_months": "0", "neonatal_safe": "yes", "premature_infant_safe": "yes", "skin_barrier_maturity_consideration": "Vitamin E, antioxidant, safe, skin-beneficial", "transepidermal_absorption_risk_pediatric": "very_low", "dose_per_kg_body_weight_concern": "Safe - vitamin…
comedogenicity_detail
{"comedogenicity_rating": "2", "irritancy_rating": "1", "skin_type_suitability": "dry,combination,normal,mature", "acne_safe": "caution", "source": "Vitamin E"}
hair_care
{"hair_function": "color-protection", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "all", "protein_sensitivity": "neutral", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "yes", "heat_protectant": "yes", "color_safe": "neutral", …
regulatory
{"eu_status": "allowed", "us_status": "allowed"}
solubility_hlb
{"water_soluble": "no", "oil_soluble": "yes", "soluble_in": "oils, ethanol", "insoluble_in": "water, glycerin, propylene glycol", "log_p": "10.2", "melting_point_c": "2-3", "appearance": "amber viscous liquid", "source": "DSM"}
synergy
{"inci_name_2": "Ascorbyl Palmitate + BHT", "synergy_type": "color-stability", "synergy_description": "Antioxidant system for oil-phase color protection", "combined_benefit": "Enhanced color stability, oxidation prevention, extended shelf life", "efficacy_multiplier": "2.5x", "mechanism_of_action": "Multiple antioxidants provide synergistic protection against oxidation preventing discoloration", "…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Binder
Deodorizer
Flavouring and nutrient
Fragrance
Humectant
Other
Pharmaceutical
Processing aids not otherwise specified
Softener and conditioner
Regulatory List Membership (2)
EU Regulated in Personal Care
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Tocopherol (Vitamin E).
Regulatory Flags
EU Restricted
fda_food_additive
Known Synonyms
dl-Tocopherol mixture, natural (alpha, beta, gamma and delta)
Tocoferoles
Golden Tocopherol 70
Methyltocols
UNII-R0ZB2556P8
Irganox E 217DF
Grindox 497
E-Oil 805D
Covi-Ox T 90EU-C
Copherol F 1300
Controx VP
Decanox MTS 50
Dry E-Mix 20
MTS 60S
Oxynat 70IP
Riken Dry E-Mix SP-T
Riken E-Oil 705
Rikki N 70
Chemical Function
Antioxidant
Pharmaceutical
Deodorizer
Regulatory Lists
Europe; Personal care
Europe; Personal care
Canada; pharmaceutical
Canada; pharmaceutical
animal_products
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
967
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Vitamin E - Mixed Tocopherols
Food Category
vitamins_minerals
Frequently Asked Questions
Is Tocopherol (Vitamin E) allowed in the EU?
Tocopherol (Vitamin E) EU regulatory status: restricted. Maximum allowed concentration: 5.4%. This is based on EU Regulation 1223/2009 and its amendments.
What does Tocopherol (Vitamin E) do in cosmetics?
Tocopherol (Vitamin E) functions as: Antioxidant. It is classified as a Surfactant in our database. CAS number: 1406-66-2.
Is Tocopherol (Vitamin E) used outside cosmetics?
Tocopherol (Vitamin E) also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Tocopherol (Vitamin E) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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TRANS, TRANS-2,4-DECADIENAL
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Perfuming
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