What is the NOAEL for 2-Ethylhexyl fumarate?
2-Ethylhexyl fumarate has 4 NOAEL studies in the database. The lowest reported value is 19Q90W09ES UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Ethylhexyl fumarate
Also known as: BRN 1729134, 2-Butenedioic acid (E)-, bis(2-ethylhexyl) ester, 2-Butenedioic acid, bis(2-ethylhexyl) ester, EINECS 205-448-2, Di(2-ethylhexyl) fumarate (+4 more)
CAS 141-02-6
2-Ethylhexyl fumarate (CAS 141-02-6) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
2-Ethylhexyl fumarate is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H411).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
2-Ethylhexyl fumarate
CAS Number
141-02-6
DTXSID
DTXSID2051710
Molecular Formula
C20H36O4
InChI Key
ROPXFXOUUANXRR-BUHFOSPRSA-N
Monoisotopic Mass
340.26136
Synonyms
BRN 17291342-Butenedioic acid (E)-, bis(2-ethylhexyl) ester2-Butenedioic acid, bis(2-ethylhexyl) esterEINECS 205-448-2Di(2-ethylhexyl) fumarateRC Comonomer DOFBis-(2-ethylhexyl)ester kyseliny fumaroveUNII-19Q90W09ES2-Butenedioic acid (2E)-, 1,4-bis(2-ethylhexyl) ester
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Softener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 19Q90W09ES | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 19Q90W09ES | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 19Q90W09ES | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 19Q90W09ES | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Bis(2-ethylhexyl) fumarate | 205-448-2 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Emollient
Frequently Asked Questions
What regulatory lists include 2-Ethylhexyl fumarate?
2-Ethylhexyl fumarate appears on 4 regulatory/inventory lists including Arts and crafts/Office supplies - home office - pens and markers; detected; Europe, detected; Europe; Toys and children's products, Canada; Personal care; Substances in PCP - Canada (4/2014), and 1 more. Source: EPA CPDat.
Is 2-Ethylhexyl fumarate used in cosmetics?
Yes, 2-Ethylhexyl fumarate is also indexed as a cosmetic ingredient under the name Diethylhexyl Fumarate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Ethylhexyl fumarate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Ethylhexyl fumarate have different safety status in cosmetics vs industrial chemicals?
2-Ethylhexyl fumarate is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H411).
Is 2-Ethylhexyl fumarate used outside industrial chemicals?
2-Ethylhexyl fumarate also appears in cosmetics databases.