Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Diethylhexyl Fumarate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Limited published cosmetic toxicology data available. Fumaric acid esters are known contact sensitizers at low molecular weight; this higher MW diester is expected to behave differently, but formal testing should be confirmed before CPSR submission.
Regulatory Flags
Frequently Asked Questions
Is Diethylhexyl Fumarate safe in cosmetics?
Limited published cosmetic toxicology data available. Fumaric acid esters are known contact sensitizers at low molecular weight; this higher MW diester is expected to behave differently, but formal testing should be confirmed before CPSR submission. The EU classifies Diethylhexyl Fumarate as "prohibited". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is Diethylhexyl Fumarate allowed in the EU?
Diethylhexyl Fumarate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethylhexyl Fumarate do in cosmetics?
Diethylhexyl Fumarate functions as: Emollient, plasticizer, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 141-02-6.
What is the Margin of Safety for Diethylhexyl Fumarate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diethylhexyl Fumarate?
The NOAEL (No Observed Adverse Effect Level) for Diethylhexyl Fumarate is >=1000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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