Is Diethylhexyl Fumarate safe in cosmetics?
Diethylhexyl Fumarate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Diethylhexyl Fumarate
Also known as: BRN 1729134, 2-Butenedioic acid (E)-, bis(2-ethylhexyl) ester, 2-Butenedioic acid, bis(2-ethylhexyl) ester, EINECS 205-448-2, Di(2-ethylhexyl) fumarate (+4 more)
INCI: DIETHYLHEXYL FUMARATE
Diethylhexyl Fumarate (CAS 141-02-6) is a cosmetic cosmetic ingredient functioning as Emollient, plasticizer, solvent. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 141-02-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Diethylhexyl Fumarate is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H411).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Emollient, plasticizer, solvent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
bis(2-ethylhexyl) (E)-but-2-enedioate
InChIKey
ROPXFXOUUANXRR-BUHFOSPRSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — no CFR restriction; limited VCRP data
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diethylhexyl Fumarate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Diethylhexyl Fumarate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Diethylhexyl Fumarate.
Regulatory Flags
potential-allergen
Known Synonyms
BRN 1729134
2-Butenedioic acid (E)-, bis(2-ethylhexyl) ester
2-Butenedioic acid, bis(2-ethylhexyl) ester
EINECS 205-448-2
Di(2-ethylhexyl) fumarate
RC Comonomer DOF
Bis-(2-ethylhexyl)ester kyseliny fumarove
UNII-19Q90W09ES
2-Butenedioic acid (2E)-, 1,4-bis(2-ethylhexyl) ester
Chemical Function
Softener and conditioner
Regulatory Lists
Arts and crafts/Office supplies - home office - pens and markers; detected; Europe
detected; Europe; Toys and children's products
detected; Europe; Toys and children's products
Canada; Personal care; Substances in PCP - Canada (4/2014)
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Diethylhexyl Fumarate allowed in the EU?
Diethylhexyl Fumarate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethylhexyl Fumarate do in cosmetics?
Diethylhexyl Fumarate functions as: Emollient, plasticizer, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 141-02-6.
Is Diethylhexyl Fumarate used outside cosmetics?
Diethylhexyl Fumarate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Diethylhexyl Fumarate have different safety status in cosmetics vs industrial chemicals?
Diethylhexyl Fumarate is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H411).
Compliance Tools
Check Diethylhexyl Fumarate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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