What is the NOAEL for Diisobutyl adipate?
Diisobutyl adipate has 9 NOAEL studies in the database. The lowest reported value is 865 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Diisobutyl adipate
Also known as: 4-02-00-01962, BRN 1791084, EINECS 205-450-3, UNII-8OPY05ZY7S
CAS 141-04-8
Diisobutyl adipate (CAS 141-04-8) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
10 fields
Name
Diisobutyl adipate
CAS Number
141-04-8
DTXSID
DTXSID9036690
Molecular Formula
C14H26O4
InChI Key
RDOFJDLLWVCMRU-UHFFFAOYSA-N
Monoisotopic Mass
258.183109
Synonyms
4-02-00-01962BRN 1791084EINECS 205-450-3UNII-8OPY05ZY7S
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
27 records
SolventSoftener and conditionerPlasticizerDeodorizerFragranceProcessing aids not otherwise specifiedFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| consumer_product | P&G | Proctor & Gamble |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 865 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| 8OPY05ZY7S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8OPY05ZY7S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8OPY05ZY7S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8OPY05ZY7S | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 13500 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Diisobutyl adipate | 205-450-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3184260
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Diisobutyl adipate?
Diisobutyl adipate appears on 8 regulatory/inventory lists including detected; Europe; Toys and children's products, inert_ingredient; non_food_use; Pesticides, Indirect additives food contact (10/2018), and 5 more. Source: EPA CPDat.
Is Diisobutyl adipate used in cosmetics?
Yes, Diisobutyl adipate is also indexed as a cosmetic ingredient under the name Diisobutyl Adipate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Diisobutyl adipate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Diisobutyl adipate used outside industrial chemicals?
Diisobutyl adipate also appears in cosmetics, pharmaceutical databases.