Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Diisobutyl Adipate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
No significant safety concerns; recommended cosmetic use levels 0.005–8%.
Regulatory Flags
Frequently Asked Questions
Is Diisobutyl Adipate safe in cosmetics?
No significant safety concerns; recommended cosmetic use levels 0.005–8%. The EU classifies Diisobutyl Adipate as "permitted". Safety rating: EXCELLENT. 1 toxicological study endpoint(s) are available in our database.
Is Diisobutyl Adipate allowed in the EU?
Diisobutyl Adipate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diisobutyl Adipate do in cosmetics?
Diisobutyl Adipate functions as: Emollient / skin conditioning agent; also evaluated as a food-grade flavouring agent. It is classified as a cosmetic ingredient in our database. CAS number: 141-04-8.
What is the Margin of Safety for Diisobutyl Adipate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diisobutyl Adipate?
The NOAEL (No Observed Adverse Effect Level) for Diisobutyl Adipate is >=1000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
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Related Ingredients
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