What is the NOAEL for Propanedioic acid?
Propanedioic acid has 92 NOAEL studies in the database. The lowest reported value is 1 % via oral in rat. Source: UnifiedCodex:CIR:beta.noael_studies.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Propanedioic acid
Also known as: Malonic acid, 4-02-00-01874, BRN 1751370, EINECS 205-503-0, USAF EK-695 (+15 more)
CAS 141-82-2
Propanedioic acid (CAS 141-82-2) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
Propanedioic acid is classified GHS Danger (H302, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
92
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Propanedioic acid
CAS Number
141-82-2
DTXSID
DTXSID7021659
Molecular Formula
C3H4O4
InChI Key
OFOBLEOULBTSOW-UHFFFAOYSA-N
Monoisotopic Mass
104.010959
Synonyms
Malonic acid4-02-00-01874BRN 1751370EINECS 205-503-0USAF EK-695UNII-9KX7ZMG0MKDicarboxylateDicarboxylic acidH2maloHOOC-CH2-COOHKyselina malonovaKyselina malonova [czech]
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is severely irritating to the eyes and respiratory tract. The substance is irritating to the skin. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
pH regulating agentFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| Europe | European Commission | Fl@vis |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 92 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 200 | mg/kg bw | - | - | rat | UnifiedCodex:CIR:beta.noael_studies |
| <4000 | mg/kg | - | - | rat | UnifiedCodex:CIR:beta.noael_studies |
| >8000 | mg/kg | - | dermal | rat | UnifiedCodex:CIR:beta.noael_studies |
| =4.2 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 9KX7ZMG0MK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9KX7ZMG0MK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9KX7ZMG0MK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9KX7ZMG0MK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >8.9 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =1 | % | NOAEL | oral | rat | CIR_vision_codex |
| =1 | % | NOAEL | oral | rat | CIR_vision_codex |
| =1 | % | NOAEL | oral | rat | CIR_vision_codex |
| =1 | % | NOAEL | oral | rat | CIR_vision_codex |
| =2 | % | NOAEL | oral | rat | CIR_vision_codex |
| =2 | % | NOAEL | oral | rat | CIR_vision_codex |
| =2 | % | NOAEL | oral | rat | CIR_vision_codex |
| =2 | % | NOAEL | oral | rat | CIR_vision_codex |
| =3 | % | NOAEL | oral | rat | CIR_vision_codex |
| =3 | % | NOAEL | oral | rat | CIR_vision_codex |
| =3 | % | NOAEL | oral | rat | CIR_vision_codex |
| =3 | % | NOAEL | oral | rat | CIR_vision_codex |
| =170 | mg/kg bw/d | NOAEL | oral | - | CIR_vision_codex |
| =170 | mg/kg bw/d | NOAEL | oral | - | CIR_vision_codex |
| =170 | mg/kg bw/d | NOAEL | oral | - | CIR_vision_codex |
| =170 | mg/kg bw/d | NOAEL | oral | - | CIR_vision_codex |
| =200 | mg/kg bw | NOAEL | - | rat | CIR_vision_codex |
| =200 | mg/kg bw | NOAEL | - | rat | CIR_vision_codex |
| =200 | mg/kg bw | NOAEL | - | rat | CIR_vision_codex |
| =200 | mg/kg bw | NOAEL | - | rat | CIR_vision_codex |
| =250 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| =250 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| =250 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| =250 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| =263 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| =263 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| =263 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| =263 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| =288 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| =288 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| =288 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| =288 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| =300 | mg/kg bw | NOAEL | - | rat | CIR_vision_codex |
| =300 | mg/kg bw | NOAEL | - | rat | CIR_vision_codex |
| =300 | mg/kg bw | NOAEL | - | rat | CIR_vision_codex |
| =300 | mg/kg bw | NOAEL | - | rat | CIR_vision_codex |
| >435 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| >435 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| >435 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| >435 | mg/kg bw | NOAEL | oral | rat | CIR_vision_codex |
| =500 | mg/kg bw/d | NOAEL | oral | rat | CIR_vision_codex |
Showing 50 of 92 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Malonic acid | 205-503-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
MALONIC ACID
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Propanedioic acid?
Propanedioic acid appears on 4 regulatory/inventory lists including pharmaceutical, drinking_water; Europe; manufacturing; plastic_additive, Europe, and 1 more. Source: EPA CPDat.
Is Propanedioic acid used in cosmetics?
Yes, Propanedioic acid is also indexed as a cosmetic ingredient under the name Malonic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Propanedioic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Propanedioic acid have different safety status in cosmetics vs industrial chemicals?
Propanedioic acid is classified GHS Danger (H302, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Is Propanedioic acid used outside industrial chemicals?
Propanedioic acid also appears in cosmetics, pharmaceutical, cannabis databases.