NOAEL Data REACH Registered Cosmetic Ingredient

Propanedioic acid

Also known as: Malonic acid, 4-02-00-01874, BRN 1751370, EINECS 205-503-0, USAF EK-695 (+15 more)

CAS 141-82-2

Propanedioic acid (CAS 141-82-2) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Malonic Acid →

Cross-Vertical Regulatory Divergence

Propanedioic acid is classified GHS Danger (H302, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields

Name

Propanedioic acid

CAS Number

141-82-2

Molecular Formula

C3H4O4

InChI Key

OFOBLEOULBTSOW-UHFFFAOYSA-N

Monoisotopic Mass

104.010959

Synonyms

Malonic acid4-02-00-01874BRN 1751370EINECS 205-503-0USAF EK-695UNII-9KX7ZMG0MKDicarboxylateDicarboxylic acidH2maloHOOC-CH2-COOHKyselina malonovaKyselina malonova [czech]

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE WHO/JECFA 1 records

Field	Value
Short-term Effects	The substance is severely irritating to the eyes and respiratory tract. The substance is irritating to the skin.
Routes of Exposure	The substance can be absorbed into the body by inhalation and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

pH regulating agentFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 4 records

List	Keyword	Source
pharmaceutical	US International Trade Commission	CPCat
drinking_water; Europe; manufacturing; plastic_additive	Belgaqua	CPCat
Europe	European Commission	Fl@vis
Canada; pharmaceutical	DrugBank	DrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 38 of 38 studies

Value	Unit	Endpoint	Route	Species	Source
200	mg/kg bw	-	-	rat	Regulatory source
<4000	mg/kg	-	-	rat	Regulatory source
>8000	mg/kg	-	dermal	rat	Regulatory source
=4.2	mg/m3	DNEL systemic	inhalation	Human	ToxValDB GESTIS DNEL
9KX7ZMG0MK	UNII	FDA UNII substance identifier	-	-	openFDA substances
>8.9	mg/L	LC50	Inhalation	-	NTP ICE acute inhalation
=1	%	NOAEL	oral	rat	CIR Safety Assessment
=2	%	NOAEL	oral	rat	CIR Safety Assessment
=3	%	NOAEL	oral	rat	CIR Safety Assessment
=170	mg/kg bw/d	NOAEL	oral	-	CIR Safety Assessment
=200	mg/kg bw	NOAEL	-	rat	CIR Safety Assessment
=250	mg/kg bw	NOAEL	oral	rat	CIR Safety Assessment
=263	mg/kg bw	NOAEL	oral	rat	CIR Safety Assessment
=288	mg/kg bw	NOAEL	oral	rat	CIR Safety Assessment
=300	mg/kg bw	NOAEL	-	rat	CIR Safety Assessment
>435	mg/kg bw	NOAEL	oral	rat	CIR Safety Assessment
=500	mg/kg bw/d	NOAEL	oral	rat	CIR Safety Assessment
=610	mg/kg bw	NOAEL	oral	rat	CIR Safety Assessment
=1000	mg/kg bw	NOAEL	-	rat	CIR Safety Assessment
=2000	mg/kg bw/d	NOAEL	-	rat	CIR Safety Assessment
=3333	mg/kg bw	NOAEL	oral	rat	CIR Safety Assessment
<4000	mg/kg	NOAEL	-	rat	CIR Safety Assessment
>8000	mg/kg	NOAEL	dermal	rat	CIR Safety Assessment
170	mg/kg bw/d	developmental toxicity	oral	-	Regulatory source
250	mg/kg bw	developmental toxicity	oral	rat	Regulatory source
263	mg/kg bw	developmental toxicity	oral	rat	Regulatory source
288	mg/kg bw	developmental toxicity	oral	rat	Regulatory source
300	mg/kg bw	developmental toxicity	-	rat	Regulatory source
1000	mg/kg bw	developmental toxicity	-	rat	Regulatory source
2000	mg/kg bw/d	developmental toxicity	-	rat	Regulatory source
1	%	inhalation toxicity	oral	rat	Regulatory source
3	%	oral toxicity	oral	rat	Regulatory source
>435	mg/kg bw	oral toxicity	oral	rat	Regulatory source
3333	mg/kg bw	oral toxicity	oral	rat	Regulatory source
1	%	repeated dose toxicity	oral	rat	Regulatory source
2	%	repeated dose toxicity	oral	rat	Regulatory source
500	mg/kg bw/d	repeated dose toxicity	oral	rat	Regulatory source
610	mg/kg bw	repeated dose toxicity	oral	rat	Regulatory source

Showing 38 of 38 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA 1 records

Status	Name	EC Number	Link
Registered	Malonic acid	205-503-0	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE ChEMBL / DailyMed MALONIC ACID

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Propanedioic acid?

Propanedioic acid has 38 NOAEL studies in the database. The lowest reported value is 1 % via oral in rat. Source: CIR Safety Assessment.

What regulatory lists include Propanedioic acid?

Propanedioic acid appears on 4 regulatory/inventory lists including pharmaceutical, drinking_water; Europe; manufacturing; plastic_additive, Europe, and 1 more. Source: EPA CPDat.

Is Propanedioic acid used in cosmetics?

Yes, Propanedioic acid is also indexed as a cosmetic ingredient under the name Malonic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Propanedioic acid come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Propanedioic acid have different safety status in cosmetics vs industrial chemicals?

Propanedioic acid is classified GHS Danger (H302, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.

Is Propanedioic acid used outside industrial chemicals?

Propanedioic acid also appears in cosmetics, pharmaceutical, cannabis databases.