Is Malonic Acid safe in cosmetics?
Malonic Acid has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Malonic Acid
Also known as: 4-02-00-01874, BRN 1751370, EINECS 205-503-0, USAF EK-695, UNII-9KX7ZMG0MK (+14 more)
INCI: MALONIC ACID
Malonic Acid (CAS 141-82-2) is a cosmetic cosmetic ingredient functioning as Buffering (pH control). NOAEL 10 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 141-82-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Malonic Acid is classified GHS Danger (H302, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Buffering (pH control)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
propanedioic acid
InChIKey
OFOBLEOULBTSOW-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not prohibited or restricted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Malonic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Malonic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =170 mg/kg bw/d | oral | - | developmental toxicity | CIR_vision_codex |
| NOAEL | =170 mg/kg bw/d | oral | - | developmental toxicity | CIR_vision_codex |
| NOAEL | =170 mg/kg bw/d | oral | - | developmental toxicity | CIR_vision_codex |
| NOAEL | =170 mg/kg bw/d | oral | - | developmental toxicity | CIR_vision_codex |
| NOAEL | =200 mg/kg bw | - | rat | NOAEL study | CIR_vision_codex |
| NOAEL | =200 mg/kg bw | - | rat | NOAEL study | CIR_vision_codex |
| NOAEL | =200 mg/kg bw | - | rat | NOAEL study | CIR_vision_codex |
| NOAEL | =200 mg/kg bw | - | rat | NOAEL study | CIR_vision_codex |
| NOAEL | =250 mg/kg bw | oral | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =250 mg/kg bw | oral | rat | developmental toxicity | CIR_vision_codex |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is severely irritating to the eyes and respiratory tract. The substance is irritating to the skin.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Malonic Acid across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
1085
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
A skin and severe eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
pH regulating agent
Expert Verdict
Expert safety assessment and concern-level summary for Malonic Acid.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Malonic Acid by CAS number or substance name.
Studies
59
Lowest NOAEL
10
Highest NOAEL
3333
Units vary across source rows: mg/kg bw, mg/kg bw/d, mg/kg bw/day
CIR_vision_codex
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
4-02-00-01874
BRN 1751370
EINECS 205-503-0
USAF EK-695
UNII-9KX7ZMG0MK
Dicarboxylate
Dicarboxylic acid
H2malo
HOOC-CH2-COOH
Kyselina malonova
Kyselina malonova [czech]
Malonate
Malonate dicarboxylic acid
Metahnedicarboxylic acid
Methanedicarbonic acid
Propanedioate
Propanedioic acid dithallium salt
Propanediolic acid
Thallium malonate
Chemical Function
pH regulating agent
Flavouring and nutrient
Regulatory Lists
pharmaceutical
drinking_water; Europe; manufacturing; plastic_additive
Europe
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
MALONIC ACID
ChEMBL ID
CHEMBL7942
Frequently Asked Questions
Is Malonic Acid allowed in the EU?
Malonic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Malonic Acid do in cosmetics?
Malonic Acid functions as: Buffering (pH control). It is classified as a cosmetic ingredient in our database. CAS number: 141-82-2.
What is the NOAEL for Malonic Acid?
The NOAEL (No Observed Adverse Effect Level) for Malonic Acid is =170 mg/kg bw/d based on a developmental toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: CIR_vision_codex.
Is Malonic Acid used outside cosmetics?
Malonic Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Malonic Acid have different safety status in cosmetics vs industrial chemicals?
Malonic Acid is classified GHS Danger (H302, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Malonic Acid compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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