Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Malonic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 10 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >667 mg/kg bw/day | oral | mouse | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
GHS classification H302 (harmful if swallowed) and H318 (causes serious eye damage); corrosive/irritant at high concentrations - in-use concentration must be controlled carefully. A synthetic, saturated dicarboxylic acid (propanedioic acid, C₃H₄O₄); melting point 132-135 °C; highly water-soluble; density 1.6 g/cm³. Not to be confused with malic acid (CAS 97-67-6), which is a different compound despite similar naming.
Frequently Asked Questions
Is Malonic Acid safe in cosmetics?
GHS classification H302 (harmful if swallowed) and H318 (causes serious eye damage); corrosive/irritant at high concentrations - in-use concentration must be controlled carefully. A synthetic, saturated dicarboxylic acid (propanedioic acid, C₃H₄O₄); melting point 132-135 °C; highly water-soluble; density 1.6 g/cm³. Not to be confused with malic acid (CAS 97-67-6), which is a different compound despite similar naming. The EU classifies Malonic Acid as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Malonic Acid allowed in the EU?
Malonic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Malonic Acid do in cosmetics?
Malonic Acid functions as: Buffering (pH control). It is classified as a cosmetic ingredient in our database. CAS number: 141-82-2.
What is the Margin of Safety for Malonic Acid?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Malonic Acid?
The NOAEL (No Observed Adverse Effect Level) for Malonic Acid is 100 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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