What is the NOAEL for N-(2-Hydroxyethyl)acetamide?
N-(2-Hydroxyethyl)acetamide has 10 NOAEL studies in the database. The lowest reported value is A9O0818TWD UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
N-(2-Hydroxyethyl)acetamide
Also known as: Acetamide, N-(2-hydroxyethyl)-, 2-Acetamidoethanol, 2-Acetylaminoethanol, 2-N-Acetylaminoethanol, Acetamide MEA (+15 more)
CAS 142-26-7
N-(2-Hydroxyethyl)acetamide (CAS 142-26-7) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
N-(2-Hydroxyethyl)acetamide is classified GHS Danger (H315, H318, H335) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
N-(2-Hydroxyethyl)acetamide
CAS Number
142-26-7
DTXSID
DTXSID6044804
Molecular Formula
C4H9NO2
InChI Key
PVCJKHHOXFKFRP-UHFFFAOYSA-N
Monoisotopic Mass
103.063329
Synonyms
Acetamide, N-(2-hydroxyethyl)-2-Acetamidoethanol2-Acetylaminoethanol2-N-AcetylaminoethanolAcetamide MEAAcetylcolamineESSIGSAEURE-(2-HYDROXYAETHYL)-AMIDETHANOLAMINE, N-ACETYL-N-(β-Hydroxyethyl)acetamideN-2-HydroxyethylacetamideN-Acetyl-2-aminoethanolN-Acetylethanolamine
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
22 records
Softener and conditionerSurfactant (surface active agent)HumectantAnti-static agentViscosity modifierThickening agentFoamant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| A9O0818TWD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A9O0818TWD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A9O0818TWD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| A9O0818TWD | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =26950 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >750 | mg/kg bw/d | NOAEL | oral | rat | CIR_vision_codex |
| >750 | mg/kg bw/d | NOAEL | oral | rat | CIR_vision_codex |
| >750 | mg/kg bw/d | NOAEL | oral | rat | CIR_vision_codex |
| >750 | mg/kg bw/d | NOAEL | oral | rat | CIR_vision_codex |
| >750 | mg/kg bw/d | developmental toxicity | oral | rat | UnifiedCodex:CIR:beta.noael_studies |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | N-2-hydroxyethylacetamide | 205-530-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
humectant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3188272
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include N-(2-Hydroxyethyl)acetamide?
N-(2-Hydroxyethyl)acetamide appears on 2 regulatory/inventory lists including CEDI, Indirect additives food contact (10/2018). Source: EPA CPDat.
Is N-(2-Hydroxyethyl)acetamide used in cosmetics?
Yes, N-(2-Hydroxyethyl)acetamide is also indexed as a cosmetic ingredient under the name Acetamide MEA. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for N-(2-Hydroxyethyl)acetamide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does N-(2-Hydroxyethyl)acetamide have different safety status in cosmetics vs industrial chemicals?
N-(2-Hydroxyethyl)acetamide is classified GHS Danger (H315, H318, H335) in the chemicals database but is allowed in EU cosmetics.
Is N-(2-Hydroxyethyl)acetamide used outside industrial chemicals?
N-(2-Hydroxyethyl)acetamide also appears in cosmetics, pharmaceutical databases.