What is the NOAEL for Heptane?
Heptane has 17 NOAEL studies in the database. The lowest reported value is 1170 mg/m3 via inhalation in Rat. Source: ToxValDB PPRTV (CPHEA).
NOAEL Data
REACH Registered
Cosmetic Ingredient
Heptane
Also known as: Dipropyl methane, EINECS 205-563-8, Gettysolve-C, Heptanen, UNII-456148SDMJ
CAS 142-82-5
Heptane (CAS 142-82-5) is a chemical substance. Key regulatory status: REACH registered, 20 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.
Cross-Vertical Regulatory Divergence
Heptane is classified GHS Danger (H225, H304, H315, H336, H400, H410, H320, H319) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
17
SOURCE
Chemical inventory jurisdictions
Regulatory lists
20
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Heptane
CAS Number
142-82-5
DTXSID
DTXSID6024127
Molecular Formula
C7H16
InChI Key
IMNFDUFMRHMDMM-UHFFFAOYSA-N
Monoisotopic Mass
100.125201
Synonyms
Dipropyl methaneEINECS 205-563-8Gettysolve-CHeptanenUNII-456148SDMJ
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Highly flammable liquid and vapour May be fatal if swallowed and enters airways Causes skin irritation May cause drowsiness or dizziness Very toxic to aquatic life with long lasting effects |
| Short-term Effects | The substance is irritating to the skin. The vapour is irritating to the respiratory tract. If swallowed the substance easily enters the airways and could result in aspiration pneumonitis. The substance may cause effects on the central nervous system. |
| Long-term Effects | The substance defats the skin, which may cause dryness or cracking. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour and by ingestion. |
OSHA Exposure Limits
Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.
SOURCE
OSHA / NIOSH / ACGIH occupational exposure limits
8 records
| Agency | Metric | Value | ppm | mg/m3 | Skin |
|---|---|---|---|---|---|
| OSHA | TWA | 500 ppm (2000 mg/m³) | 500 | 2000 | N |
| NIOSH | TWA | 85 ppm (350 mg/m³) | 85 | 350 | N |
| NIOSH | CEILING | 440 ppm (1800 mg/m³) [15 minutes] | 440 | 1800 | N |
| ACGIH | TWA | 400 ppm [1979] | 400 | - | N |
| ACGIH | STEL | 500 ppm [1979] | 500 | - | N |
| CAL/OSHA | TWA | 400 ppm (1600 mg/m³) | 400 | 1600 | N |
| CAL/OSHA | STEL | 500 ppm (2000 mg/m³) | 500 | 2000 | N |
| NIOSH | IDLH | 750 ppm | 750 | - | - |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
16 records
SolventViscosity modifierPropellants, non-motive (blowing agents)Degradant/impurityCleaning agentFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
20 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - shoes; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 17 of 17 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =12069.7 | mg/m3 | BMC (10) | inhalation | Mouse | ToxValDB TX TCEQ |
| =1170 | mg/m3 | BMCL (1SD HEC) | inhalation | Rat | ToxValDB PPRTV (CPHEA) |
| =2085 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB GESTIS DNEL |
| 456148SDMJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 456148SDMJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 456148SDMJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 456148SDMJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >29.29 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 103 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| 196.5991 | mg/L | LC50 | Inhalation | - | NTP ICE acute inhalation |
| =43033 | mg/m3 | LEL | inhalation | Human | ToxValDB DOE Protective Action Criteria |
| =6147.58 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB TX TCEQ |
| =12295.2 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB EU SCOEL |
| =0.4 | mg/m3 | RfC (provisional) | inhalation | Human | ToxValDB PPRTV (CPHEA) |
| =4 | mg/m3 | RfC (provisional) | inhalation | Human | ToxValDB PPRTV (CPHEA) |
| =0.0003 | mg/kg bw/day | RfD | oral | Human | ToxValDB RSL |
| =0.003 | mg/kg bw/day | RfD | oral | Human | ToxValDB RSL |
Showing 17 of 17 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Heptane | 205-563-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Solvent
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
HEPTANE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Heptane?
Heptane appears on 14 regulatory/inventory lists including IFRA Transparency, inert_ingredient; non_food_use; Pesticides, Indirect additives food contact (10/2018), and 11 more. Source: EPA CPDat.
What are the occupational exposure limits for Heptane?
Occupational exposure limits for Heptane are set by OSHA, NIOSH, ACGIH. 8 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.
Is Heptane used in cosmetics?
Yes, Heptane is also indexed as a cosmetic ingredient under the name Heptane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Heptane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Heptane have different safety status in cosmetics vs industrial chemicals?
Heptane is classified GHS Danger (H225, H304, H315, H336, H400, H410, H320, H319) in the chemicals database but is allowed in EU cosmetics.
Is Heptane used outside industrial chemicals?
Heptane also appears in cosmetics, pharmaceutical, cannabis databases.