Moderate Cosmetic Ingredient GHS Classified

Heptane

INCI: HEPTANE

CAS Number

142-82-5

Function

Solvent

Safety Rating

MODERATE

Regulatory Status

🇪🇺 EU Status permitted

🇺🇸 US Status permitted

US Notes Permitted — not specifically restricted in 21 CFR for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

adequate

Dermal Absorption

moderate

Sensitization

none

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

DANGER

Pictograms

flam;flame; excl mark;warn; cancer;health haz; enviro;aqua

Hazard Statements

Highly flammable liquid and vapour May be fatal if swallowed and enters airways Causes skin irritation May cause drowsiness or dizziness Very toxic to aquatic life with long lasting effects

Short-term Exposure Effects

The substance is irritating to the skin. The vapour is irritating to the respiratory tract. If swallowed the substance easily enters the airways and could result in aspiration pneumonitis. The substance may cause effects on the central nervous system.

Long-term Exposure Effects

The substance defats the skin, which may cause dryness or cracking.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Expert Verdict

Highly flammable with aspiration hazard; causes skin irritation and CNS depression at high inhalation exposure; prolonged contact causes skin defatting and dermatitis; very toxic to aquatic life.

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Concern Level: High

Regulatory Flags

ifra_fragrance

Frequently Asked Questions

Is Heptane safe in cosmetics?

Highly flammable with aspiration hazard; causes skin irritation and CNS depression at high inhalation exposure; prolonged contact causes skin defatting and dermatitis; very toxic to aquatic life. The EU classifies Heptane as "permitted". Safety rating: MODERATE.

Is Heptane allowed in the EU?

Heptane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Heptane do in cosmetics?

Heptane functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 142-82-5.

What is the Margin of Safety for Heptane?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Is Heptane classified as hazardous under GHS?

Heptane carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour May be fatal if swallowed and enters airways Causes skin irritation May cause drowsiness or dizziness Very toxic to aquatic life with long lasting effects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check Heptane compliance across multiple jurisdictions:

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Ingredient Decoder

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82 Allergen Checker

Check for EU declarable fragrance allergens

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Substance Compliance

Check compliance across 55 jurisdictions

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MoS Calculator

Calculate Margin of Safety using SCCS methodology

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Heavy Metal Limits

Compare limits across jurisdictions

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