NOAEL Data Cosmetic Ingredient

1,3-Benzodioxol-5-amine

Also known as: 5-Aminobenzodioxole, 5-Amino-1,3-benzodioxole, 1-Amino-3,4-dimethylenedioxybenzene, 1-Amino-3,4-methylenedioxybenzene, 4-Amino-1,2-methylenedioxybenzene (+6 more)

CAS 14268-66-7

1,3-Benzodioxol-5-amine (CAS 14268-66-7) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for 3,4-Methylenedioxyaniline →

Cross-Vertical Regulatory Divergence

1,3-Benzodioxol-5-amine is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H315, H319, H332, H335).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 17 fields

Name

1,3-Benzodioxol-5-amine

CAS Number

14268-66-7

DTXSID

DTXSID8065743

Molecular Formula

C7H7NO2

InChI Key

XGNXYCFREOZBOL-UHFFFAOYSA-N

Monoisotopic Mass

137.047678

Synonyms

5-Aminobenzodioxole5-Amino-1,3-benzodioxole1-Amino-3,4-dimethylenedioxybenzene1-Amino-3,4-methylenedioxybenzene4-Amino-1,2-methylenedioxybenzeneAniline, 3,4-(methylenedioxy)-EINECS 238-161-6MethylenedioxyanilineNSC 155176UNII-2Q750587K83,4-Methylenedioxyaniline

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records

List	Keyword	Source
banned; Europe; Personal care	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 4 of 4 studies

Value	Unit	Endpoint	Route	Species	Source
2Q750587K8	UNII	FDA UNII substance identifier	-	-	openFDA substances
2Q750587K8	UNII	FDA UNII substance identifier	-	-	openFDA substances
2Q750587K8	UNII	FDA UNII substance identifier	-	-	openFDA substances
2Q750587K8	UNII	FDA UNII substance identifier	-	-	openFDA substances

Showing 4 of 4 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Frequently Asked Questions

What is the NOAEL for 1,3-Benzodioxol-5-amine?

1,3-Benzodioxol-5-amine has 4 NOAEL studies in the database. The lowest reported value is 2Q750587K8 UNII. Source: openFDA substances.

What regulatory lists include 1,3-Benzodioxol-5-amine?

1,3-Benzodioxol-5-amine appears on 1 regulatory/inventory list including banned; Europe; Personal care. Source: EPA CPDat.

Is 1,3-Benzodioxol-5-amine used in cosmetics?

Yes, 1,3-Benzodioxol-5-amine is also indexed as a cosmetic ingredient under the name 3,4-Methylenedioxyaniline. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,3-Benzodioxol-5-amine come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does 1,3-Benzodioxol-5-amine have different safety status in cosmetics vs industrial chemicals?

1,3-Benzodioxol-5-amine is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H315, H319, H332, H335).

Is 1,3-Benzodioxol-5-amine used outside industrial chemicals?

1,3-Benzodioxol-5-amine also appears in cosmetics databases.