Poor Cosmetic Ingredient

3,4-Methylenedioxyaniline

INCI: 3,4-METHYLENEDIOXYANILINE

CAS Number
14268-66-7
Function
Hair dye intermediate
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status prohibited
US Notes Not specifically prohibited by FDA; however, aromatic amines are flagged by CIR and EWG

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Critical — potent sensitizer with N-nitrosamine formation risk. Must not combine with nitrosating agents; nitrosamine content must be <50 ppb per SCCS. Parent amine should not be used directly; only Annex III-authorized derivatives permitted at restricted concentrations.

⚠️
Concern Level: High

Regulatory Flags

potential-allergen eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is 3,4-Methylenedioxyaniline safe in cosmetics?

Critical — potent sensitizer with N-nitrosamine formation risk. Must not combine with nitrosating agents; nitrosamine content must be <50 ppb per SCCS. Parent amine should not be used directly; only Annex III-authorized derivatives permitted at restricted concentrations. The EU classifies 3,4-Methylenedioxyaniline as "prohibited". Safety rating: POOR.

Is 3,4-Methylenedioxyaniline allowed in the EU?

3,4-Methylenedioxyaniline EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does 3,4-Methylenedioxyaniline do in cosmetics?

3,4-Methylenedioxyaniline functions as: Hair dye intermediate. It is classified as a cosmetic ingredient in our database. CAS number: 14268-66-7.

What is the Margin of Safety for 3,4-Methylenedioxyaniline?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check 3,4-Methylenedioxyaniline compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

Hydroxypropyl Bis(N-Hydroxyethyl-P-Phenylenediamine) HCl
Moderate
1,7-Naphthalenediol
Moderate
2,6-Diaminopyridine ⚠️
Poor
3-Nitro-P-Cresol
Moderate
2,6-Dimethoxy-3,5-Pyridinediamine HCl
Moderate
Browse all 30,000+ ingredients →
📱

Is 3,4-Methylenedioxyaniline in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 3,4-Methylenedioxyaniline in your formulation.

Ingredient Decoder MoS Calculator