Is 3,4-Methylenedioxyaniline safe in cosmetics?
3,4-Methylenedioxyaniline has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited.
Poor
Cosmetic Ingredient
3,4-Methylenedioxyaniline
Also known as: 5-Aminobenzodioxole, 5-Amino-1,3-benzodioxole, 1-Amino-3,4-dimethylenedioxybenzene, 1-Amino-3,4-methylenedioxybenzene, 4-Amino-1,2-methylenedioxybenzene (+5 more)
INCI: 3,4-METHYLENEDIOXYANILINE
3,4-Methylenedioxyaniline (CAS 14268-66-7) is a cosmetic cosmetic ingredient functioning as Hair dye intermediate. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 14268-66-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
3,4-Methylenedioxyaniline is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H315, H319, H332, H335).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dye intermediate
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
1,3-benzodioxol-5-amine
InChIKey
XGNXYCFREOZBOL-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Not specifically prohibited by FDA; however, aromatic amines are flagged by CIR and EWG
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 3,4-Methylenedioxyaniline.
Calculate MoS for your specific formulation with the MoS Calculator.
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1248
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1248
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 3,4-Methylenedioxyaniline.
Regulatory Flags
potential-allergen
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
5-Aminobenzodioxole
5-Amino-1,3-benzodioxole
1-Amino-3,4-dimethylenedioxybenzene
1-Amino-3,4-methylenedioxybenzene
4-Amino-1,2-methylenedioxybenzene
Aniline, 3,4-(methylenedioxy)-
EINECS 238-161-6
Methylenedioxyaniline
NSC 155176
UNII-2Q750587K8
Chemical Function
Dye
Regulatory Lists
banned; Europe; Personal care
Australian Status
AICIS status: listed
Frequently Asked Questions
Is 3,4-Methylenedioxyaniline allowed in the EU?
3,4-Methylenedioxyaniline EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 3,4-Methylenedioxyaniline do in cosmetics?
3,4-Methylenedioxyaniline functions as: Hair dye intermediate. It is classified as a cosmetic ingredient in our database. CAS number: 14268-66-7.
Is 3,4-Methylenedioxyaniline used outside cosmetics?
3,4-Methylenedioxyaniline also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 3,4-Methylenedioxyaniline have different safety status in cosmetics vs industrial chemicals?
3,4-Methylenedioxyaniline is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H315, H319, H332, H335).
Compliance Tools
Check 3,4-Methylenedioxyaniline compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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