What is the NOAEL for Dodecanoic acid?
Dodecanoic acid has 54 NOAEL studies in the database. The lowest reported value is 4.58105982043437 uM. Source: NTP_ICE_endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dodecanoic acid
Also known as: Lauric acid, 1-Undecanecarboxylic acid, 4-02-00-01082, BRN 1099477, EINECS 205-582-1 (+15 more)
CAS 143-07-7
Dodecanoic acid (CAS 143-07-7) is a chemical substance. Key regulatory status: REACH registered, 33 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Dodecanoic acid is classified GHS Danger (H315, H318, H319) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
54
SOURCE
chemical inventory jurisdictions
Regulatory lists
33
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Dodecanoic acid
CAS Number
143-07-7
DTXSID
DTXSID5021590
Molecular Formula
C12H24O2
InChI Key
POULHZVOKOAJMA-UHFFFAOYSA-N
Monoisotopic Mass
200.17763
Synonyms
Lauric acid1-Undecanecarboxylic acid4-02-00-01082BRN 1099477EINECS 205-582-1FEMA No. 2614Hydrofol acid 1255Hydrofol acid 1295Ninol AA62 ExtraNSC-5026Univol U-314Wecoline 1295
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
51 records
Surfactant (surface active agent)EmulsifierCleaning agentFragranceFlavouring and nutrientPlasticizerHumectantLubricating agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
33 records
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; Pesticides | EPA | CPCat |
| detected; emissions; Europe; Other indirect contact consumer goods; water | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| detected; Toys and children's products | Scientific Reports | Published Articles |
| Europe | European Commission | Fl@vis |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| pharmaceutical | US International Trade Commission | CPCat |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; plastic_additive | European Chemicals Agency | European Chemicals Agency (ECHA) |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 54 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 6.85427603139454 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 4.58105982043437 | uM | ACC | - | - | NTP_ICE_endocrine |
| =17.632 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 1160N9NU9U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1160N9NU9U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1160N9NU9U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1160N9NU9U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 1 | unitless | GHS Classification | Ocular | Rabbit | NTP_ICE_eye_irritation |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.017 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 2500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 5000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 4.4 | % | Positive reaction | Dermal | Human | NTP_ICE_skin_irritation |
| 5 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 6.9 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
| 14.6 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
| 98.5 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 99.8 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 103.1 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 105.26 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 105.7 | % | Viability | Dermal | - | NTP_ICE_skin_irritation |
| 94 | % | Viability (18 hours) | Dermal | - | NTP_ICE_skin_irritation |
| 28.5 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 49.6 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 51.2 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 108.4 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 120.8 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 141.7 | % | Viability (240 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 87.4 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 90.4 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 92 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 97.1 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 102 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 104 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 104.6 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 105.7 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 110.7 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 111.3 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 116 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 118.6 | % | Viability (3 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 78.9 | % | Viability (42 hours) | Dermal | - | NTP_ICE_skin_irritation |
| 21.9 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 22.7 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 31.5 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 34.3 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 34.6 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 44.3 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 82.7 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
| 94.4 | % | Viability (60 minutes) | Dermal | - | NTP_ICE_skin_irritation |
Showing 50 of 54 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Lauric acid | 205-582-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
DODECANOATE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
11
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Dodecanoic acid?
Dodecanoic acid appears on 22 regulatory/inventory lists including detected; Europe; Other direct contact consumer goods, detected; Europe; Vehicle - car interior, air; detected; emissions; Europe; Vehicle - car interior, and 19 more. Source: EPA CPDat.
Is Dodecanoic acid used in cosmetics?
Yes, Dodecanoic acid is also indexed as a cosmetic ingredient under the name Lauric Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dodecanoic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Dodecanoic acid have different safety status in cosmetics vs industrial chemicals?
Dodecanoic acid is classified GHS Danger (H315, H318, H319) in the chemicals database but is allowed in EU cosmetics.
Is Dodecanoic acid used outside industrial chemicals?
Dodecanoic acid also appears in cosmetics, pharmaceutical, food safety, cannabis databases.