Good Emollient NOAEL Data

Lauric Acid

INCI: LAURIC ACID

CAS Number
143-07-7
Function
Saturated long-chain fatty acid (C12:0). Dominant fatty acid in virgin coconut oil (approximately 46-48%). Primary antimicrobial component via membrane disruption. Functions as emollient, skin-conditioning agent, and antimicrobial agent.
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Primary fatty acid of virgin coconut oil (approximately 46-48%). FDA GRAS for food use. Clinical trials demonstrate TEWL reduction superior to mineral oil in atopic dermatitis. Antimicrobial activity via membrane disruption. C12 fatty acids are substrates for Malassezia; lauric acid-rich oils are contraindicated in fungal-acne (Malassezia folliculitis) sensitive formulations.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Lauric Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 5000 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 2500 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
dose_tested 5000 mg/kg bw/day oral rat Subchronic COSMOS_DB
dose_tested 2500 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

Expert Verdict

Primary fatty acid of virgin coconut oil with clinical evidence of superior TEWL reduction compared to mineral oil in atopic dermatitis. Antimicrobial activity occurs via membrane disruption; however, must be avoided in Malassezia folliculitis-prone formulations as C12 fatty acids serve as substrates for this fungus.

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Concern Level: Low

Regulatory Flags

antimicrobial malassezia-substrate contraindicated-fungal-acne coconut-derived eu_children_restricted epa_safer_alternative ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Lauric Acid safe in cosmetics?

Primary fatty acid of virgin coconut oil with clinical evidence of superior TEWL reduction compared to mineral oil in atopic dermatitis. Antimicrobial activity occurs via membrane disruption; however, must be avoided in Malassezia folliculitis-prone formulations as C12 fatty acids serve as substrates for this fungus. The EU classifies Lauric Acid as "permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.

Is Lauric Acid allowed in the EU?

Lauric Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Lauric Acid do in cosmetics?

Lauric Acid functions as: Saturated long-chain fatty acid (C12:0). Dominant fatty acid in virgin coconut oil (approximately 46-48%). Primary antimicrobial component via membrane disruption. Functions as emollient, skin-conditioning agent, and antimicrobial agent.. It is classified as a Emollient in our database. CAS number: 143-07-7.

What is the Margin of Safety for Lauric Acid?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Lauric Acid?

The NOAEL (No Observed Adverse Effect Level) for Lauric Acid is 5000 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.

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