NOAEL Data Cosmetic Ingredient

2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol

CAS 1444596-49-9

2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol (CAS 1444596-49-9) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, AICIS, SCCS.

View cosmetic safety profile for HC Red No. 18 →

SOURCE NOAEL studies

NOAEL studies

SOURCE Chemical inventory jurisdictions

Regulatory lists

SOURCE EU CLP Annex VI

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 5 fields

Name

2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol

CAS Number

1444596-49-9

Molecular Formula

C9H7ClN4OS2

InChI Key

XQNTVGDQOPVBIP-OUKQBFOZSA-N

Monoisotopic Mass

285.9749809

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 21 of 21 studies

Value	Unit	Endpoint	Route	Species	Source
=0.013	mg/kg bw	NOAEL	oral	rat	SCCS Opinion
=0.022	mg/kg bw	NOAEL	oral	rat	SCCS Opinion
=2.31	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion
=3	mg/kg bw/day	NOAEL	oral	rat	SCCS Opinion
=3	mg/kg/day	NOAEL	-	rat	SCCS Opinion
=3	mg/kg bw/d	NOAEL	oral	rat	SCCS Opinion
=50	mg/kg bw/day	NOAEL	-	rat	SCCS Opinion
=77	%	NOAEL	oral	rat	SCCS Opinion
=100	mg/kg bw/day	NOAEL	oral	rat	SCCS Opinion
=0.013	mg/kg bw	dermal absorption	oral	rat	Regulatory source
=2.31	mg/kg bw/d	dermal absorption	oral	rat	Regulatory source
=3	mg/kg bw/d	dermal absorption	oral	rat	Regulatory source
3	mg/kg bw/day	developmental toxicity	oral	rat	Regulatory source
50	mg/kg bw/day	developmental toxicity	-	rat	Regulatory source
50	mg/kg bw/day	developmental toxicity	oral	rat	Regulatory source
3	mg/kg bw/day	genotoxicity	oral	rat	Regulatory source
77	%	irritation	oral	rat	Regulatory source
3	mg/kg/day	repeated dose toxicity	-	rat	Regulatory source
3	mg/kg/day	repeated dose toxicity	oral	rat	Regulatory source
77	%	repeated dose toxicity	oral	rat	Regulatory source
100	mg/kg bw/day	repeated dose toxicity	oral	rat	Regulatory source

Showing 21 of 21 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed_with_terms

Conditions

Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE SCCS Opinion 2 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1673/24	22 January 2025	safe with restrictions	1.5% oxidative / 0.5% non-oxidative	sensitization
SCCS/1569/15	16 March 2016	insufficient data	-	purity inadequately quantified

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

restricted

Max

Frequently Asked Questions

What is the NOAEL for 2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol?

2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol has 21 NOAEL studies in the database. The lowest reported value is 0.013 mg/kg bw via oral in rat. Source: SCCS Opinion.

Is 2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol used in cosmetics?

Yes, 2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol is also indexed as a cosmetic ingredient under the name HC Red No. 18. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol come from?

Safety data is sourced from EPA ToxValDB, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol used outside industrial chemicals?

2-Chloro-4-{(E)-[3-(methylsulfanyl)-1,2,4-thiadiazol-5-yl]diazenyl}phenol also appears in cosmetics databases.