Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for HC Red No. 18. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 3 mg/kg bw/day | oral | rat | subchronic | SCCS_PDF_extraction |
| NOAEL | 0.013 mg/kg bw/day | oral | rat | subchronic | SCCS_PDF_extraction |
| NOAEL | 2.31 mg/kg bw/day | oral | rat | subchronic | SCCS_PDF_extraction |
| NOAEL | 0.022 mg/kg bw/day | oral | rat | subchronic | SCCS_PDF_extraction |
| NOAEL | 3 mg/kg bw/day | - | - | - | SCCS_PDF_extraction |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
formulations? In light of the data provided, the SCCS considers HC Red 18 safe when used as an ingredient at 1.5% in oxidative hair dye and at 0.5% in non-oxidative hair dye formulations. (2) Does the SCCS have any further scientific concerns with regard to the use of
Expert Verdict
The SCCS did not raise further scientific concerns in its most recent opinion regarding the provided purity data. Standard direct dye safety considerations (sensitization, nitrosamine formation) apply.. One of the newest HC Red dyes under regulatory evaluation. The SCCS opinion was driven by updated purity characterization data in Submission II.
Regulatory Flags
Frequently Asked Questions
Is HC Red No. 18 safe in cosmetics?
The SCCS did not raise further scientific concerns in its most recent opinion regarding the provided purity data. Standard direct dye safety considerations (sensitization, nitrosamine formation) apply.. One of the newest HC Red dyes under regulatory evaluation. The SCCS opinion was driven by updated purity characterization data in Submission II. The EU classifies HC Red No. 18 as "restricted". Safety rating: MODERATE. 5 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.
Is HC Red No. 18 allowed in the EU?
HC Red No. 18 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Red No. 18 do in cosmetics?
HC Red No. 18 functions as: Hair dyeing - direct dye for both oxidative and non-oxidative hair color formulations. It is classified as a cosmetic ingredient in our database. CAS number: 1444596-49-9.
What is the Margin of Safety for HC Red No. 18?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for HC Red No. 18?
The NOAEL (No Observed Adverse Effect Level) for HC Red No. 18 is 3 mg/kg bw/day based on a subchronic study via oral route in rat. A total of 5 study endpoints are available. Source: SCCS_PDF_extraction.
Compliance Tools
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Related Ingredients
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