INCI: HC RED NO. 18
HC Red No. 18 (CAS 1444596-49-9) is a cosmetic cosmetic ingredient functioning as Hair dyeing - direct dye for both oxidative and non-oxidative hair color. NOAEL 3 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted; 1 safety opinion reviewed (sccs). Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 1444596-49-9 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for HC Red No. 18.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for HC Red No. 18. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.013 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.013 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.013 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.013 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.022 mg/kg bw | oral | rat | NOAEL study | SCCS_vision_codex |
| NOAEL | =0.022 mg/kg bw | oral | rat | NOAEL study | SCCS_vision_codex |
| NOAEL | =0.022 mg/kg bw | oral | rat | NOAEL study | SCCS_vision_codex |
| NOAEL | =0.022 mg/kg bw | oral | rat | NOAEL study | SCCS_vision_codex |
| NOAEL | =2.31 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =2.31 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
formulations? In light of the data provided, the SCCS considers HC Red 18 safe when used as an ingredient at 1.5% in oxidative hair dye and at 0.5% in non-oxidative hair dye formulations. (2) Does the SCCS have any further scientific concerns with regard to the use of
Pre-calculated NOAEL → SED → MoS audit trail for HC Red No. 18 across SCCS product categories, with measured dermal absorption where available.
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| default | 10.0 | method=default | - | - |
Expert safety assessment and concern-level summary for HC Red No. 18.
Public NOAEL study rows linked to HC Red No. 18 by CAS number or substance name.
Units vary across source rows: mg/kg bw/day, mg/kg/day, mg/kg bw
| Absorption % | Method | Vehicle |
|---|---|---|
| 10.0 | method=default | - |
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
HC Red No. 18 has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.
HC Red No. 18 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
HC Red No. 18 functions as: Hair dyeing - direct dye for both oxidative and non-oxidative hair color formulations. It is classified as a cosmetic ingredient in our database. CAS number: 1444596-49-9.
The NOAEL (No Observed Adverse Effect Level) for HC Red No. 18 is =0.013 mg/kg bw based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
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