What is the NOAEL for HC Orange No. 6?
HC Orange No. 6 has 19 NOAEL studies in the database. The lowest reported value is PKS7O14JK4 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
HC Orange No. 6
CAS 1449653-83-1
HC Orange No. 6 (CAS 1449653-83-1) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, SCCS.
SOURCE
NOAEL studies
NOAEL studies
19
SOURCE
Chemical inventory jurisdictions
Regulatory lists
0
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
2 fields
Name
HC Orange No. 6
CAS Number
1449653-83-1
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Dye
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 19 of 19 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| PKS7O14JK4 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =10 | mg/kg bw | NOAEL | oral | rat | SCCS Opinion |
| =19 | % | NOAEL | oral | rat | SCCS Opinion |
| =50 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =100 | mg/kg/day | NOAEL | - | - | SCCS Opinion |
| =100 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =100 | mg/kg | NOAEL | dermal | - | SCCS Opinion |
| =300 | mg/kg bw/day | NOAEL | - | rat | SCCS Opinion |
| =300 | mg/kg/day | NOAEL | - | - | SCCS Opinion |
| 10 | mg/kg bw | developmental toxicity | oral | rat | Regulatory source |
| =50 | mg/kg bw/d | developmental toxicity | oral | rat | Regulatory source |
| 100 | mg/kg/day | developmental toxicity | - | - | Regulatory source |
| 100 | mg/kg | developmental toxicity | - | - | Regulatory source |
| =100 | mg/kg bw/d | developmental toxicity | oral | rat | Regulatory source |
| 100 | mg/kg | developmental toxicity | dermal | - | Regulatory source |
| 300 | mg/kg/day | developmental toxicity | - | - | Regulatory source |
| 300 | mg/kg/day | developmental toxicity | - | rat | Regulatory source |
| 300 | mg/kg bw/day | genotoxicity | - | rat | Regulatory source |
| 19 | % | repeated dose toxicity | oral | rat | Regulatory source |
Showing 19 of 19 studies
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1579/16 | 7 November 2016 | safe | 0.5% | not a sensitiser |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
0.5%
Category
Colorant
Frequently Asked Questions
Is HC Orange No. 6 used in cosmetics?
Yes, HC Orange No. 6 is also indexed as a cosmetic ingredient under the name HC Orange No. 6. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for HC Orange No. 6 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is HC Orange No. 6 used outside industrial chemicals?
HC Orange No. 6 also appears in cosmetics databases.